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UID:20260731T184047EDT-6448dbGGcH@132.216.98.100
DTSTAMP:20260731T224047Z
DESCRIPTION:Hosted by the Department of Biochemistry\n	Mandatory for all Bio
 chemistry Graduate Students\n\nDavid Thomas\, PhD FRSC\n	Department of Bioc
 hemistry\n	ɬÀï·¬\n	\n	Abstract\n	Cells have homeostatic mechanisms
  that monitor the integrity organelles and proteins and repair or degrade 
 faulty components\, termed proteostasis.  One example that we have intensi
 vely studied is the ER quality system\, the Calnexin Cycle.  Protein traff
 icking diseases such as cystic fibrosis arise from recognition of mutant p
 roteins by the quality control mechanism and the retention of the mutant b
 ut otherwise function protein in the ER.   We have identified correctors o
 f the trafficking of ER retained mutant proteins and identified two types 
 of mechanism\, pharmacological chaperones that bind the mutant molecules a
 nd proteostasis modulators that act on the quality control mechanisms.\n
DTSTART:20141029T160000Z
DTEND:20141029T170000Z
LOCATION:Meakins Theatre\, Room 521\, McIntyre Medical Building\, CA\, QC\,
  Montreal\, H3G 1Y6\, 3655 promenade Sir William Osler
SUMMARY:DAVID L. THOMSON LECTURE - David Thomas\, PhD FRSC / Seminar Title:
  'Protein quality control and trafficking diseases'
URL:/biochemistry/channels/event/david-l-thomson-lectu
 re-david-thomas-phd-frsc-seminar-title-protein-quality-control-and-traffic
 king-238495
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