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DTSTAMP:20260728T210631Z
DESCRIPTION:Axel A. Thomson\, PhDPrincipal Investigator Research ScientistM
 RC Human Reproductive Sciences UnitEdinburgh\, UKTitle: Stromal-Epithelial
  interactions and the regulation of prostate development and cancer – usin
 g mesenchymal molecules to slow tumour growth     The role of the tumour m
 icroenvironment in cancer initiation and progression is increasingly recog
 nized as critically important and yet is poorly understood at the mechanis
 tic or molecular level. Tumour stroma (cancer associated fibroblasts\, CAF
 s) stimulate prostate carcinogenesis and stromal histology is an independe
 nt predictor of prostate cancer patient prognosis. There is considerable i
 nterest in identifying pathways in tumour stroma that act as paracrine reg
 ulators of tumour epithelia\, as these may become new therapeutics or diag
 nostics. Our studies have utilized the similarities between mesenchyme inv
 olved in directing prostate organogenesis and CAFs involved in tumourigene
 sis\, since both involve stromal/epithelial interactions and paracrine sig
 nalling. We have used gene profiling to identify molecules expressed in de
 velopmental prostate mesenchyme and CAFs\, and focussed upon those which a
 re secreted or surface bound – since these may function as paracrine regul
 ators of epithelia (and/or autocrine regulators of stroma). Furthermore\, 
 we have recently demonstrated that we can inhibit the pro-tumourigenic sig
 nalling of CAFs using the pathways that we identified and characterized in
  developmental prostatic mesenchyme. This is a novel approach to tumour co
 ntrol.  My approach in regard to studying stromal mechanisms in prostate c
 ancer is almost unique\, since the majority of research is focussed upon t
 umour epithelia. We have combined basic developmental biology with tumour 
 studies and used developmental systems to identify and test pathways. Thes
 e have also been tested in a primary human prostate tumour reconstitution 
 system in which to examine effects upon tumourigenesis via CAFs. This has 
 led us to propose a new paradigm in which developmental mesenchymal pathwa
 ys can be used to regulate epithelial tumourigenesis by reducing CAF pro-t
 umourigenic signalling.   
DTSTART:20121016T160000Z
DTEND:20121016T170000Z
SUMMARY:Goodman Cancer Centre Seminar
URL:/biochemistry/channels/event/goodman-cancer-centre
 -seminar-218519
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