BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20251118T203747EST-8509NawsXW@132.216.98.100 DTSTAMP:20251119T013747Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegistration coming soon.\n\n\nCall for Abstracts\n \nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at Neuro Epilepsy Day 2026. \n\nWe enc ourage abstracts at any stage of a project’s development—from literature r eviews and research questions to pilot data and ongoing studies.\n\nSubmis sion deadline: March 23\, 2026\n\nSubmit Your Abstract Here\n\nSelected ab stracts will be featured in the poster session\, and five outstanding post ers will be invited to give a short oral presentation during the program. \n\n\n\n \n Programme\n Speakers\n The Pierre Gloor Lecture\n Location\n Sponsor s\n Scientific Committee\n \n\n \n Thursday\, May 28\, 2026\n\n Preliminary Pro gram \n\n \n \n \n 9:15\n Arrival & Registration\n \n \n 9:30\n \n Lab Tours\n\n Neur oimaging\, EEG/FMRI\, MEG\n \n \n \n 10:45\n \n Welcome and Introduction\n\n Bori s Bernhardt\, PhD\n Associate Professor of Neurology and Neurosurgery\n Epil epsy Group Leader (Research)\, The Neuro\n \n \n \n 11:00\n \n Keynote Lecture\n \n Irene Wang\, PhD\n Research Director and Staff Scientist\n Cleveland Clini c Epilepsy Center\n \n \n \n 1:00\n \n Lunch and Poster Session\n \n \n \n 2:00\n \n O ral Presentations\n \n \n \n 3:00\n Coffee Break\n \n \n 3:15\n \n Pierre Gloor Lect ure\n\n Brain Mosaicism in Epilepsies and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research director and Group Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4:15\n Discussion Panel\n \n \n 5:00\n \n Cocktail Recept ion (onsite)\n \n \n \n \n \n\n \n Speakers\n\n Stéphanie Baulac | Pierre Gloor Le cture\n\n Stéphanie Baulac is a Research Director at Inserm and Group Leade r at the Paris Brain Institute (ICM) of the MOSAIC Team « Genetic Mosaicis m in Epilepsy and Neurodevelopmental Disorders » Her team implements a com prehensive translational approach spanning from the identification and cha racterization of somatic mutations in brain tissues obtained from patients undergoing epilepsy surgery to in-depth functional analysis\, combining f unctional testing on patient-derived brain organoids\, and mouse models.  \n \n Brain Mosaicism in Epilepsies and Cortical Malformations\n Focal cortic al dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy\, resulting from developmental somatic mutations in mTOR pathway genes. To understand how these mutations create a mosaic pattern of affec ted cells and lead to cortical dyslamination\, we performed comprehensive single-nucleus analyses of surgical samples from genetically-characterized FCDII patients. By combining genotyping and transcriptomics at single-cel l resolution\, we revealed that mutations predominantly affect glutamaterg ic neurons and astrocytes\, creating distinct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-specif ic dysregulation of synaptic and neurodevelopmental pathways that likely c ontribute to epileptogenesis. Notably\, our analysis of cytomegalic cells uncovered pronounced alterations in mitochondrial metabolism pathways and cellular senescence. We uncover a signature associated with cellular senes cence in abnormal FCDII cells and further provide evidence in preclinical FCDII mouse models that senolytic agents could offer a novel therapeutic s trategy for this disorder.\n\n  \n\n \n \n\n \n The Pierre Gloor Lecture\n\n The Pierre Gloor Lecture celebrates the life and legacy of Pierre Gloor (1923 –2003)\, who joined The Neuro (Montreal Neurological Institute-Hospital) i n 1952 as a fellow in electroencephalography and neurophysiology. He train ed under Wilder Penfield and Herbert Jasper and earned his PhD from ɬÀï·¬ University in 1957. Gloor collaborated closely with clinical and research teams at The Neuro in advancing the understanding and treatment of epilep sy\, gaining international recognition for his contributions to the field. \n\n Brain Mosaicism in Epilepsies and Cortical Malformations\n\n Speaker: S téphanie Baulac\, PhD\n Research director and Group Leader\n Inserm and Pari s Brain Institute (ICM)\n\n Focal cortical dysplasia type II (FCDII) is a c ortical malformation causing refractory epilepsy\, resulting from developm ental somatic mutations in mTOR pathway genes. To understand how these mut ations create a mosaic pattern of affected cells and lead to cortical dysl amination\, we performed comprehensive single-nucleus analyses of surgical samples from genetically-characterized FCDII patients. By combining genot yping and transcriptomics at single-cell resolution\, we revealed that mut ations predominantly affect glutamatergic neurons and astrocytes\, creatin g distinct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-specific dysregulation of synaptic and ne urodevelopmental pathways that likely contribute to epileptogenesis. Notab ly\, our analysis of cytomegalic cells uncovered pronounced alterations in mitochondrial metabolism pathways and cellular senescence. We uncover a s ignature associated with cellular senescence in abnormal FCDII cells and f urther provide evidence in preclinical FCDII mouse models that senolytic a gents could offer a novel therapeutic strategy for this disorder.\n\n  \n\n \n \n\n \n Location\n\n The Montreal Neurological Institute and Hospital is at 3801 University Street\, north of Pine Avenue West\, on the ɬÀï·¬ Univer sity campus opposite the former Royal Victoria Hospital.\n\n Montreal is se rved by highway Routes 10\, 15\, 20 and 40\, and by Greyhound Bus\, Via Ra il and the P-E-Trudeau airport. In the city\, bus and metro service is pro vided by the Société de transport de Montréal (STM).\n\n Wheelchair access \n\n A wheelchair accessible entrance is on University Street north of the main entrance. Another wheelchair accessible entrance is in the loading ar ea behind the building: to enter the loading area\, turn into the driveway south of the main entrance. Please note\, there is no parking in the load ing area.\n\n Parking\n\n Parking near the MNI is sometimes difficult. There are parking meters on University Street and a parking lot north of the ma in entrance. To enter the lot\, turn right into the driveway toward Molson Stadium.\n\n Information about parking fees\n\n Taxi Stand\n\n There is a ta xi stand on University Street across from the main entrance. You may call a cab from the free taxi phone in the main lobby near the Security Desk.\n \n Access by Public Transportation (STM website)\n\n Bus\n\n There are four b us stops within walking distance:\n\n \n Bus 144 stops at Pine Avenue and Un iversity Street\n Bus 356 stops at Sherbrooke Street and University Street (Nightbus)\n Bus 107 stops at Pine Avenue and Docteur Penfield\n Bus 24 stop s at Sherbrooke Street and University Street\n \n\n Metro\n\n Take the Metro Green Line to the ɬÀï·¬ station. Walk north on University Street and cros s Pine Avenue. The main entrance is on the right\, past the flags.\n\n Jean ne Timmins Amphitheatre\n\n \n Enter the main lobby\, turn left\, and go dow n the hallway to the end.\n Turn right and go down the second hallway until you see another hallway on the left.\n This hallway leads to the Jeanne Ti mmins Foyer.\n On your right are the Jeanne Timmins Amphitheatre entrance d oors.\n \n \n\n \n Sponsors \n \n\n \n Scientific Committee\n\n Sam Audrain\n\n Ale xander Barnett\n\n Boris Bernhardt\n\n Sara Larivière\n\n Raluca Pana\n\n Debb ie Rashcovsky\n\n Myriam Srour\n\n  \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/brain/channels/event/neuro-epilepsy-day-2026-epil epsy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR