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UID:20260318T204902EDT-0090cbCwrN@132.216.98.100
DTSTAMP:20260319T004902Z
DESCRIPTION:Abstract:\n\nNatural products and their derivatives have long b
 een used as medicinal agents\, and they still make up a significant fracti
 on of clinically approved drugs. Natural product total synthesis provides 
 a rich and unparalleled opportunity to develop new synthetic transformatio
 ns\, conceive novel and general strategies to access complex structures\, 
 and study the mechanism of action of bioactive targets. The combination of
  the tools and principles of chemistry\, together with the tools of modern
  biology\, allows us to create complex synthetic and natural molecules\, c
 omprising processes with novel biological\, chemical and physical properti
 es. This lecture will illustrate the opportunities that lie at this interf
 ace between synthetic organic chemistry\, chemical biology as well as drug
  discovery endeavors by describing a series of examples that we are active
 ly working on in our laboratory. Through total synthesis applying the stat
 e-of-the-art new synthetic strategies such as sequential C-H functionaliza
 tions\, we are identifying a number of new natural product-derived antibio
 tics targeting tuberculosis or Gram-negative bacteria\, which directly or 
 indirectly block drug resistance with novel mode of actions. Such molecule
 s\, are applied in combination with first generation antibiotics to overco
 me resistance and rescue the activity of our current antibiotic arsenal.\n
 \nBio:\n\nProf. Dr. Xiaoguang Lei was born and raised in Beijing\, China. 
 He obtained BSc degree in chemistry from Peking University in 2001. He the
 n moved to Boston and conducted his PhD research on natural product synthe
 sis and chemical biology under the supervision of Prof. John. A. Porco at 
 Boston University. He received Ph.D. in 2006\, and then conducted his post
 doctoral training in bioorganic chemistry with Prof. Samuel J. Danishefsky
  at Columbia University in New York City. In early 2009\, Dr. Lei returned
  back to China\, and started his independent research career as a Principa
 l Investigator and Director of Chemistry Center at the National Institute 
 of Biological Sciences (NIBS) in Beijing. In early 2014\, he received a te
 nured full professorship from Peking University\, and moved his research g
 roup to the College of Chemistry at Peking University. He also joined the 
 Peking-Tsinghua Center for Life Sciences as a senior PI. The major researc
 h areas of Prof. Lei's laboratory are: natural product total synthesis\, c
 hemical biology and drug discovery. He has accomplished many total synthes
 es of the structurally complex and bioactive natural products and systemat
 ically used small molecule probes including natural products to dissect th
 e fundamental cellular processes such as apoptosis and programmed necrosis
  (necroptosis)\, and illuminated a number of new molecular mechanisms. He 
 has also developed many first-in-class drug candidates for the treatment o
 f cancers and infectious diseases.\n\nProf. Lei has received many academic
  awards including: the 2018 David Ginsburg Lectureship Award\, the 2018 CC
 S-BASF Young Investigator Award\, the 2017 Tetrahedron Young Investigator 
 Award in Bioorganic and Medicinal Chemistry\, the 2017 Swiss Chemical Soci
 ety Lectureship Award\, the 2015 Chemical Society of Japan Lectureship Awa
 rd\, the 2014 Roche Young Investigator Award\, the 2013 International Chem
 ical Biology Society (ICBS) Young Chemical Biologist Award\, the 2013 Serv
 ier Young Investigator Award\, the 2013 Thieme Chemistry Journal Award\, a
 nd the 2010 IUPAC Young Chemist Award. Now he is an Editor for Bioorganic 
 & Medicinal Chemistry.\n
DTSTART:20190319T170000Z
DTEND:20190319T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Xiaoguang Lei - Natural Product Synthesis
  as a Driving Force to Address the Antibiotic Resistance Crisis 
URL:/chemistry/channels/event/chemical-society-seminar
 -xiaoguang-lei-natural-product-synthesis-driving-force-address-antibiotic-
 293028
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