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UID:20250920T202152EDT-0837CzFS50@132.216.98.100
DTSTAMP:20250921T002152Z
DESCRIPTION:Abstract:\n\nMicrobial natural products serve as a dominant sou
 rce of pharmaceutical agents and comprise some of our most celebrated cure
 s. Recent studies\, however\, have been plagued by the frequent rediscover
 y of old molecules. One underlying reason is that most natural product bio
 synthetic genes in a given bacterium are not significantly expressed under
  standard laboratory growth conditions. These so-called ‘silent’ or ‘crypt
 ic’ gene clusters represent a large reservoir of bioactive metabolites and
  methods that unlock them would have a profound impact on natural product 
 research and thereby on drug discovery. In this talk\, I will present new 
 strategies that my group has developed for activating silent biosynthetic 
 gene clusters and uncovering novel 'hidden' natural products with activiti
 es that\, in some cases\, surpass those of clinically used drugs. Aside fr
 om new natural products\, application of these approaches to diverse bacte
 ria has also unveiled small molecule elicitors and the underlying mechanis
 ms through which they turn on microbial natural product biosynthesis.\n\nB
 io:\n\nMohammad R. Seyedsayamdost is Professor of Chemistry and Molecular 
 Biology at Princeton University. He obtained a combined B.S./M.S. degree i
 n Biochemistry from Brandeis University\, completing his thesis research w
 ith Prof. Liz Hedstrom. He then conducted graduate research under the guid
 ance of Prof. JoAnne Stubbe and received a Ph.D. in chemistry from MIT. Af
 ter postdoctoral training with Prof. Jon Clardy and Prof. Roberto Kolter a
 t Harvard Medical School\, he started his independent career at Princeton.
  Prof. Seyedsayamdost's research has been recognized by a number of awards
 \, most recently with the prestigious MacArthur Fellowship.\n
DTSTART:20220405T170000Z
DTEND:20220405T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Mohammad R. Seyedsayamdost - Discovering 
 New Chemistry in the Microbial World
URL:/chemistry/channels/event/chemical-society-seminar
 -mohammad-r-seyedsayamdost-discovering-new-chemistry-microbial-world-33378
 2
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