BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250818T214058EDT-1424NEKVHC@132.216.98.100 DTSTAMP:20250819T014058Z DESCRIPTION:Abstract:\n\nBreakthroughs in the understanding of human biolog y and the advent of new enabling drug modalities such as synthetic cyclic peptides have led to unprecedented opportunities for drug discovery. At th e same time\, increasing competition and cost pressures have spurred effor ts both to increase the success rate and decrease the cost and time requir ed for discovering new medicines. Improving the efficiency and speed of th e medicinal chemistry design cycle requires the invention and application of new technologies and fresh ways of thinking. The past several decades h ave seen tremendous advances in the development of catalytic reactions tha t allow the rapid assembly of diverse\, drug-like molecules through cross- coupling of functionalized cores with vast building block sets. Recently\, these methods have expanded to include those that utilize C-H bonds as th e functional handles and points of diversification. In addition\, the incr easing power of chemical high throughput experimentation has greatly expan ded the scope of these synthetic methods through allowing the rapid explor ation and customization of reaction conditions to increase synthesis succe ss rates\, and more recently to enable high throughput compound library fa brication. This presentation will utilize several case studies to illustra te the diverse ways that modern catalysis\, enabled by HTE\, can impact dr ug discovery.\n\n \n\nBio:\n\nDr. Shane Krska completed his undergraduate studies in chemistry at the South Dakota School of Mines and Technology. H e obtained his Ph.D. in inorganic chemistry from the Massachusetts Institu te of Technology under the direction of Prof. Dietmar Seyferth and conduct ed postdoctoral research with Prof. Robert Bergman at the University of Ca lifornia\, Berkeley. He began his career at Merck Research Laboratories as a Senior Research Chemist in 1999\, where he initially worked in the Reac tion Engineering Laboratory in the Department of Chemical Engineering R&D. In 2002\, he helped found the Merck Catalysis Laboratory in the Process R esearch department with a focus on developing high-throughput experimentat ion (HTE) techniques to enable applications of homogeneous catalysis in ph armaceutical synthesis. In 2012\, he founded the Late-Stage Functionalizat ion (LSF) group within Discovery Chemistry to bring enabling synthetic che mistries and workflows to drug discovery. He currently serves as Distingui shed Scientist in NJ Discovery Chemistry\, overseeing the expansion of HTE chemistry capabilities across global Discovery Chemistry as well as exter nal collaborations.\n\nDr. Krska has authored more than 80 publications an d 10 patents. Professional honors he has received include being named an A CS Young Industrial Investigator (2008)\, as well as a co-recipient of the R&D Council of N.J. Thomas Alva Edison Patent Award (2009 and 2022)\, EPA Presidential Green Chemistry awards for JANUVIATM (2006) and EMENDTM (200 5) manufacturing processes and the Catalysis Society of Metropolitan NY Ex cellence in Catalysis Award (2012). Dr. Krska has served on the industrial advisory board of the NSF Center for Enabling New Technologies through Ca talysis (CENTC) and the Center for Selective C-H Functionalization (CCHF). He is also a member of the board of the Medicinal and Bioorganic Chemistr y Foundation (MBCF). Through his extensive engagement with the broader sci entific community\, Dr. Krska enjoys sharing his passion for scientific ex cellence\, innovation and drug discovery with students and is an ardent ad vocate and mentor for scientists from under-represented backgrounds.\n\n  \n DTSTART:20231031T170000Z DTEND:20231031T183000Z LOCATION:OM 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 801 rue Sherbrooke Ouest SUMMARY:Chemical Society Seminar: Shane Krska - Leveraging Advances in Cata lysis and High Throughput Experimentation to Impact Drug Discovery URL:/chemistry/channels/event/chemical-society-seminar -shane-krska-leveraging-advances-catalysis-and-high-throughput-349247 END:VEVENT END:VCALENDAR