BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250508T062034EDT-4993W3f7gu@132.216.98.100 DTSTAMP:20250508T102034Z DESCRIPTION:Abstract: \n\nThe McKeague Lab leverages nucleic acids to devel op innovative biosensing tools and therapeutic strategies. Nucleic acids c an be enzymatically or chemically synthesized and are particularly excepti onal biomacromolecules due to their programmability and versatility. As su ch\, our work spans infection\, blood diseases\, and molecular monitoring in complex matrices. Over the past six years at ɬ﷬\, we have developed gene-sensing and gene-targeting oligonucleotides\, designed via predictiv e base-pairing interactions\, with chemical modification for improved func tion. We also work with DNA and RNA aptamers that fold into functional 3D conformations and recognize a diversity protein and small molecule targets . This presentation will cover one biosensor and one therapeutics “choose your own adventure”. Be sure to bring a phone or other device that can rea d QR codes and make use of “Slido”.\n\n \n\nBio:\n\nAssistant Professor Ma ureen McKeague obtained a PhD in Chemistry (2012) at Carleton University w orking with Prof. Maria DeRosa. Her research applied DNA nanotechnology to detect food toxins. She wanted to apply her interest in nucleic acids to synthetic biology\, so she moved to the Smolke Lab at Stanford University from 2012-2016 for an NSERC postdoctoral fellowship award. She then transi tioned to ETH Zurich in Switzerland for 2 years as a senior researcher wor king in Prof. Shana Sturla’s lab. Here\, she studied alkylating DNA damage . She joined ɬ﷬ as a unique joint appointee in both the Dep artment of Pharmacology and Therapeutics and the Department of Chemistry. She is the Vice-President of the International Society on Aptamers\, an As sociate Editor for the Molecular Therapy Nucleic Acids journal\, and on th e Editorial Advisory Board of ACS’ Chemical Research in Toxicology. She is currently a Canada Research Chair.\n DTSTART:20241210T180000Z DTEND:20241210T193000Z LOCATION:OM 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 801 rue Sherbrooke Ouest SUMMARY:Chemical Society Seminar: Maureen McKeague- Biosensing and Therapeu tic Development with DNA and RNA URL:/chemistry/channels/event/chemical-society-seminar -maureen-mckeague-biosensing-and-therapeutic-development-dna-and-rna-36058 4 END:VEVENT END:VCALENDAR