BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20251007T075344EDT-7231B9PnTG@132.216.98.100
DTSTAMP:20251007T115344Z
DESCRIPTION:Abstract:\n\nA solution-assembled system comprised of computati
 onally designed coiled coil bundle motifs\, also known as ‘bundlemers’\, w
 ill be discussed as model colloidal nanoparticle systems for the formation
  of hierarchical materials. The molecules and nanostructures are non-natur
 al amino acid sequences and provide opportunities for controlled solution 
 behavior and arbitrary nanostructure creation with peptides. With control 
 of the display of the amino acid side chains (both natural and non-natural
 ) throughout the peptide bundles\, desired physical and covalent (through 
 appropriate ‘click’ chemistry) interactions are designed to control interp
 article interactions in solution\, which involve both individual bundlemer
  particles as well as polymers of connected bundlemers. With proper design
  of individual bundlmer particles\, two target nanomaterials are being cre
 ated. First\, interbundlemer end-to-end stacking is observed between parti
 cles through physical interactions to form lyotropic liquid crystal phases
 . Important for liquid crystal formation is the design of single charge bu
 ndlemer particles (e.g.\, with only positive/basic amino acids) that lack 
 of opposite charges on the particle surfaces so that there are no attracti
 ve electrostatic patches to disrupt the LC alignment. The liquid crystal p
 hases span nematic to hexagonal columnar to smectic depending on peptide c
 oncentration as well as on specific peptide design (e.g.\, number of negat
 ive or positive charges\, spatial display of charge\, amino acid type to c
 reate charge). Second\, nanoporous lattices can be formed through simply s
 olution mixing. The lattices display crystalline-like structure but with r
 egular pores on the nanoscale. The lattice structures are formed through t
 wo different assembly mechanisms\; the functionalization of bundlemer pari
 tcles with hydrophobic side chains on their exterior for lattice formation
  through interparticle hydrophobic interactions or through the mixing of o
 ppositely charged\, single charged bundlemers through electrostatic comple
 xation. Included in the discussion will be new\, single charge peptide mol
 ecule design\, hierarchical assembly pathway design\, control of nanostruc
 ture\, and characterization wtih cryotransmission electron micorscopy\, tr
 ansmission electron microscopy\, small-angle x-ray scattering\, and molecu
 lar dynamics simulations.\n\n \n\nBio:\n\nDarrin Pochan is currently Disti
 nguished Professor in the Materials Science and Engineering Department as 
 well as having appointments in the Delaware Biotechnology Institute\, Depa
 rtment of Chemistry & Biochemistry\, and the Department of Biomedical Engi
 neering at the University of Delaware. Since joining the MSE department in
  1999 after a Ph.D. in Polymer Science and Engineering at the University o
 f Massachusetts-Amherst and a National Research Council Post-doctoral fell
 owship at the National Institute of Standards and Technology in Gaithersbu
 rg\, MD\, he has developed a research program around the construction of n
 ew materials and nanostructures via molecular solution assembly mechanisms
 . Areas of focus are biomolecular and polymer self-assembly\, biomaterials
 \, and materials for nanotechnology and sustainable materials. His honors 
 include an NSF Career Award\, the DuPont Young Faculty Award\, the Dillon 
 medal from the American Physical Society and Fellowship in the American Ph
 ysical Society\, American Chemical Society\, Royal Society of Chemistry\, 
 American Institute of Medical and Biological Engineering\, and the Nationa
 l Academy of Inventors. Darrin recently served as Chair of MSE at UD from 
 2014-2022 and as Editor in Chief of Soft Matter from 2017-2022 published b
 y the Royal Society of Chemistry in the United Kingdom.\n
DTSTART:20251007T170000Z
DTEND:20251007T183000Z
LOCATION:OM 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 
 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Darrin Pochan- Biomolecules for non-biolo
 gical things: Peptide ‘Bundlemer’ design for model nanoparticle creation a
 nd hierarchical solution assembly
URL:/chemistry/channels/event/chemical-society-seminar
 -darrin-pochan-biomolecules-non-biological-things-peptide-bundlemer-design
 -368160
END:VEVENT
END:VCALENDAR