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UID:20251007T181742EDT-8801ksG037@132.216.98.100
DTSTAMP:20251007T221742Z
DESCRIPTION:The presentation contains two parts. The first part showcases o
 ur efforts in developing an enantioselective route for the efficient produ
 ction of complex drug substance (DS) on large scale.  The process features
  an efficient construction of a sterically hindered multi-heterocyclic API
  with two chiral centers via Hantzsch reaction\, highly asymmetric hydroge
 nation of a ketone\, lactone formation\, and asymmetric reduction of a hem
 iketal influenced by the substrate’s intrinsic chirality.\n	The second part
  focusses on research toward a practical method for asymmetric synthesis o
 f P-stereogenic chiral phosphine oxides as key starting materials for synt
 hesis of P-stereogenic phosphine ligand catalysts.\n
DTSTART:20151106T163000Z
DTEND:20151106T180000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Dr. Steve Han - Practical by Design: Effi
 cient Enantioselective Synthesis of Complex Drug Substances on Large Scale
  and Research towards a General Method for the Synthesis of P-Stereogenic 
 Chiral Phosphine Oxides
URL:/chemistry/channels/event/chemical-society-seminar
 -dr-steve-han-practical-design-efficient-enantioselective-synthesis-comple
 x-255051
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