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UID:20250821T122111EDT-8794VzdW8t@132.216.98.100
DTSTAMP:20250821T162111Z
DESCRIPTION:High throughput screening of large libraries of complex molecul
 es is the most common starting point of drug discovery. The identified sma
 ll molecule “hits” are then further investigated with the targets of inter
 est using various techniques\, including binding affinity and in vitro bio
 logical activity. In this presentation\, we will discuss a novel platform-
 ALIS*\, an Affinity Selection–Mass Spectrometry (AS-MS) platform for the d
 iscovery and characterization of protein–ligand interactions. ALIS takes a
 dvantage of the high sensitivity and selectivity inherent to MS\, directly
  identifying compounds interacting with a target protein from chemical mix
 tures\, such as combinatorial libraries\, natural product extracts\, and l
 ead/drug metabolite mixture etc. ALIS affinity ranking techniques identify
  higher affinity compounds in the mixture and minimize the need for synthe
 sis and purification resources for the most interesting ligands. ALIS plat
 form has delivered thousands of novel hits for corporate projects at Merck
 \, Schering-Plough\, Pfizer\, Aventis and other major pharmaceutical indus
 tries\, and several of these programs were advanced to clinical trials.\n
 \nRecent publications: 1) J. Med. Chem. 2016\, 59\, 1818 and 2017\, 60\, 1
 -3. 2) PNAS 2017\, 114 (3)\, E297\n
DTSTART:20170323T170000Z
DTEND:20170323T181500Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Dr. Xianshu Yang - Directly identifying n
 ovel lead compounds from chemical mixtures using an affinity selection mas
 s spectrometry platform
URL:/chemistry/channels/event/chemical-society-seminar
 -dr-xianshu-yang-directly-identifying-novel-lead-compounds-chemical-mixtur
 es-265589
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