BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260502T041701EDT-5551IJGzbm@132.216.98.100 DTSTAMP:20260502T081701Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegister Now\n\nTo watch online\, click here\n\n\nC all for Abstracts\n\nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at The Neuro Epilep sy Day 2026. \n\nWe encourage abstracts at any stage of a project’s develo pment—from literature reviews and research questions to pilot data and ong oing studies.\n\nSubmission deadline: March 30\, 2026\n\nTo submit an abst ract\, click here\n\nSelected abstracts will be featured in the poster ses sion\, and five outstanding posters will be invited to give a short oral p resentation during the program.\n\n\n\n \n Programme\n Speakers\n The Pierre G loor Lecture\n Location\n Sponsors\n Scientific Committee\n \n\n \n Thursday\, M ay 28\, 2026\n\n Preliminary Program \n\n \n \n \n 9:30\n \n Arrival & Registrati on\n\n  \n \n \n \n 10:45\n \n Welcome and Introduction\n\n Edward Fon\, MD\, FRCP (C)\n Scientific Director\, The Neuro\n\n Boris Bernhardt\, PhD\n Associate P rofessor of Neurology and Neurosurgery\n Epilepsy Group Leader (Research)\, The Neuro\n \n \n \n 11:00\n \n Keynote Lectures\n\n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n Irene Wang\, PhD\n Research Director an d Staff Scientist\n Cleveland Clinic Epilepsy Center\n\n Networks\n\n Seok-Ju n Hong\, PhD\n Associate Professor of Biomedical Engineering Department\, S KKU\n Sungkyunkwan University - ɬ﷬\n\n Surgical Approaches an d Innovations in FCD\n\n Roy William Dudley\, FRCSC\n Assistant Professor\, Department of Pediatric Surgery\, Department of Neurology & Neurosurgery\n Montreal Children's Hospital\n\n Alexander G. Weil\, FRCSC\, FACS\n Associat e Professor\, Neurosurgeon\, Researcher\, Director\n University of Montreal - Sainte-Justine Hospital Research Centre\n\n Jeffery Allan Hall\, FRCSC\n Assistant Professor of Neurology and Neurosurgery\n Epilepsy Programme\, Ne urosurgery Clinic\, Brain Tumour Clinic\n\n Sami Obaid\, MD\, PhD\, FRCSC C linical Assistant Professor\, Neurosurgeon Department of Surgery\, Faculty of Medicine Centre hospitaliser de l'Université de Montréal\n \n \n \n 1:00\n \n Lunch and Poster Session 1\n \n \n \n 2:00\n \n Oral Presentations\n \n \n \n 3:00 \n \n Coffee Break\n \n \n \n 3:15\n \n Pierre Gloor Lecture\n\n Brain Mosaicism in Epilepsies and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research d irector and Group Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4: 15\n \n Discussion Panel\n\n Alexander Weil\, MD\n\n Irene Wang\, PhD \n\n Stép hanie Baulac\, PhD \n\n Andrea Bernasconi\, MD  \n\n Neda Ladbon-Bernasconi\ , PhD    \n\n Olivier Aron\, PhD \n\n Sara Larivière\, PhD\n \n \n \n 5:00\n \n Co cktail Reception and Poster Session 2\n \n \n \n \n \n\n \n Speakers\n\n Keynotes: \n\n Irene Wang | Improving Epilepsy Surgery Planning Using MR Fingerprinti ng\n\n Dr. Irene Wang is the Research Director and Full Staff at the Clevel and Clinic Epilepsy Center and an Associate Professor of Neurology at the Cleveland Clinic Lerner College of Medicine. Her research advances surgica l treatments for MRI-negative epilepsy patients through innovative imaging and neurophysiology techniques. As a trained biomedical engineer with a s trong foundation in clinical neurophysiology and neuroimaging\, Dr. Wang h as pioneered the integration of advanced imaging into clinical practice to enhance patient care. She has authored over 120 peer-reviewed papers and serves as Associate Editor for Epilepsia. Dr. Wang has received continuous support from the National Institute of Health and serves as a charter mem ber of the NIH Imaging Technology for Neuroscience study section. Dr. Wang also chairs the MRI Data Task Force of the ILAE Big Data Commission and s erves on the Imaging Task Force of the ILAE Diagnostic Methods Commission. \n \n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n This ta lk will focus on MR Fingerprinting (MRF)\, a novel quantitative MRI techni que that enables simultaneous acquisition of multiple tissue parameters wi thin a single\, time-efficient acquisition\, providing a comprehensive mul tiparametric characterization of brain tissue properties. The talk will in clude clinical examples and studies demonstrating the added value of MRF f or detection and subtype characterization of focal cortical dysplasia\, in cluding cases with subtle or nonlesional findings on conventional MRI. The talk will further explore the potential of MRF-derived tissue metrics to inform in vivo epileptogenicity in more complex malformations of cortical development\, such as periventricular nodular heterotopia and polymicrogyr ia. Together\, these examples illustrate how MRF can enhance presurgical l ocalization\, optimize SEEG implantation\, and improve prognostication for epilepsy surgery candidates.\n\n  \n\n Stéphanie Baulac | Pierre Gloor Lect ure\n\n Stéphanie Baulac is a Research Director at Inserm and Group Leader at the Paris Brain Institute (ICM) of the MOSAIC Team « Genetic Mosaicism in Epilepsy and Neurodevelopmental Disorders » Her team implements a compr ehensive translational approach spanning from the identification and chara cterization of somatic mutations in brain tissues obtained from patients u ndergoing epilepsy surgery to in-depth functional analysis\, combining fun ctional testing on patient-derived brain organoids\, and mouse models. \n \n Brain Mosaicism in Epilepsies and Cortical Malformations\n Focal cortical dysplasia type II (FCDII) is a cortical malformation causing refractory e pilepsy\, resulting from developmental somatic mutations in mTOR pathway g enes. To understand how these mutations create a mosaic pattern of affecte d cells and lead to cortical dyslamination\, we performed comprehensive si ngle-nucleus analyses of surgical samples from genetically-characterized F CDII patients. By combining genotyping and transcriptomics at single-cell resolution\, we revealed that mutations predominantly affect glutamatergic neurons and astrocytes\, creating distinct transcriptional programs in bo th mutated and non-mutated cells. This mosaicism drives cell-type-specific dysregulation of synaptic and neurodevelopmental pathways that likely con tribute to epileptogenesis. Notably\, our analysis of cytomegalic cells un covered pronounced alterations in mitochondrial metabolism pathways and ce llular senescence. We uncover a signature associated with cellular senesce nce in abnormal FCDII cells and further provide evidence in preclinical FC DII mouse models that senolytic agents could offer a novel therapeutic str ategy for this disorder.\n\n  \n\n Seok-Jun Hong\n\n - Seok-Jun Hong\, PhD i s an associate professor in the Department of Biomedical Engineering\, and Brain Science and Engineering at Sungkyunkwan University (SKKU) and also affiliated with the Center for Neuroscience Imaging Research\, IBS in S. K orea. Before joining to SKKU\, he was a postdoctoral research fellow in Ch ild Mind Institute at New York\, working with Drs. Michael Milham and Adri ana Di Martino\, and before that\, in MNI with Dr. Boris Bernhardt. Dr. Ho ng’s previous research has focused on advanced in-vivo multimodal magnetic resonance imaging of typical and atypical brain development (epilepsy and autism)\, especially targeting a large-scale brain network organization. Building upon expertise in computer science\, statistics and neuroinformat ics\, he has developed original approaches to quantitatively describe conn ectome principles and its developmental process in the human brain. These days\, his interest is how to inform biological inductive biases learned f rom the human brain to build up large-scale biophysical neural network mod els.\n \n Advanced Brain Imaging in Neurodevelopmental Disorders: Semantic M apping\, Multimodal DBS Modeling\, and MRI Lesion Synthesis\n The recent in tegration of advanced computational neuroimaging with AI and biophysical m odeling is catalyzing a paradigmatic shift in the clinical management of c hildren with neurodevelopmental disorders. This evolution spans the entire translational continuum—from early diagnosis and mechanistic understandin g to personalized therapeutic interventions. In this talk\, I will discuss three distinct yet interconnected proof-of-concept cases that illustrate the power of these approaches. First\, to uncover the neurobiological prin ciples underlying clinical behaviors in Autism Spectrum Disorder (ASD)\, I will discuss our recent findings using naturalistic movie-viewing fMRI to construct high-dimensional semantic maps. I will demonstrate how these ma ps reveal age-dependent distortions in ASD\, their correlation with sympto m severity\, and their utility in parsing phenotypic heterogeneity into di stinct neurobiological subtypes. Second\, I will present ongoing research regarding Deep Brain Stimulation (DBS) in epilepsy. We demonstrate how mul timodal MRI can be leveraged to predict DBS efficacy by modeling the struc tural and functional pathways associated with the seizure focus. Notably\, we investigate the specific network mechanisms that dictate the success o r failure of these neuromodulatory interventions\, providing a framework f or optimized surgical targeting. Third\, I will explore the emerging role of Generative AI in medical imaging\, specifically through the lens of MRI lesion synthesis. This section highlights how synthetic data can augment epilepsy research and improve diagnostic inference\, particularly in clini cal scenarios where high-quality data is sparse. Finally\, I will conclude by outlining how these advanced computational frameworks are accelerating the realization of precision medicine in neurodevelopmental conditions an d offer my outlook on the future landscape of the field.\n\n  \n\n Sami Obaï d | Surgical approaches and innovations in FCD\n\n - Dr. Sami Obaïd\, M.D. \, Ph.D.\, is a neurosurgeon specializing in epilepsy at the Centre hospit alier de l’Université de Montréal (CHUM) and a Clinical Assistant Professo r in the Department of Surgery at the Université de Montréal. He is also a principal investigator at the CHUM Research Centre (CRCHUM)\, where he le ads the ONSET lab. His surgical practice is dedicated to epilepsy surgery\ , and in 2024\, he was awarded the prestigious FRQS Junior 1 Researcher st atus. He underwent specialized training\, including a fellowship in epilep sy surgery at Yale University and a Ph.D. in structural neuroimaging appli ed to focal epilepsy. Dr. Obaïd focuses his clinical and scientific activi ties on the identification\, selection\, presurgical evaluation\, operativ e and postoperative management of patients with drug-resistant epilepsy th rough innovative neuroimaging techniques. Recognized early for his contrib utions to research\, an asteroid was named in his honor: the minor planet Obaïd (21712). He has also been named a Distinguished Citizen of Canada fo r his scientific achievements\, listed among the “Top 20 Under 20”\, and o ne of his articles was awarded Discovery of the Year 2022 at the CRCHUS. H e recently had the honor of serving as a guest co-speaker alongside astron aut Chris Hadfield\, reflecting the reach of his work and his commitment t o science communication. A few months ago\, he also signed the Golden Book of the King of Morocco in recognition of his academic and scientific acco mplishments. At the ONSET laboratory\, Dr. Obaïd currently supervises 22 g raduate students and two research assistants\, actively contributing to th e training of the next generation of neuroscientists.\n\n  \n\n Roy Dudley |  Associate Professor\, ɬ﷬ Health Centre\n\n - Roy Dudley MD \, PhD is a an Associate Professor at ɬ﷬ and a Pediatric Ne urosurgeon at the Montreal Children's Hospital and the Montreal Neurologic al Hospital. He did his undergraduate studies in Biology and Mathematics a t Memorial University of Newfoundland\, and his PhD in Experimental Medici ne at ɬ﷬ and the MNI with the late George Karpati. He returned to Newf oundland for Medical School and came back to the MNI for Neurosurgery resi dency under the epilepsy surgery tutelage of Jeffery Hall and Andre Olivie r. He then did his Pediatric Neurosurgery Fellowship at the University of Colorado in Denver. Dr. Dudley specializes in epilepsy surgery and is an F RSQ-sponsored clinical investigator with research program focused on optim izing the presurgical evaluation of focal epilepsy patients using advanced neuroimaging and electrophysiology\, improving the intraoperative localiz ation of malformations of cortical development\, such as focal cortical dy splasia\, and overcoming the limitation of spatial coverage with SEEG.\n\n Novel Methods in SEEG to Optimize Epileptogenic Zone Localization and Func tional Mapping: Overcoming the Limitation of Spatial Coverage\n\n Surgical treatment of refractory focal epilepsy can be curative and should be consi dered as early as possible\, particularly in children. In challenging (usu ally MRI-negative) cases\, an intracerebral investigation via stereo-EEG ( SEEG) is often necessary to localize the epileptogenic zone (EZ). Despite advanced neuroimaging/electrophysiology techniques and robotic technology\ , the outcome of SEEG has improved little in 70 years\, the main drawbacks being the often-ill-informed pre-implantation hypotheses and the sparse c overage of the brain\, resulting in under-sampling or completely missing t he EZ and/or its borders\, and suboptimal stimulation for functional mappi ng. Our ongoing research aims to overcome these drawbacks of SEEG by (1) i mproving the pre-implantation hypothesis using novel methods in magnetoenc ephalography (MEG)\, such as virtual electrodes\, (2) optimizing SEEG sign al analysis via simultaneous MEG/SEEG\, and (3) refining SEEG-based functi onal mapping via novel analysis (i.e.\, video/SEEG correlates) of spontane ous movements and optimizing the stimulation parameters used to illicit ic tal versus normal responses.\n\n  \n\n Jeffery Allan Hall | Epilepsy Neurosu rgeon MNI-H\, Associate Professor ɬ﷬\n\n - Dr. Hall completed undergra duate and graduate degrees in Neuropsychology and Cognitive Neuroscience b efore medical training. His Neurosurgical Residency and Fellowship in the Surgery of Epilepsy were completed at ɬ﷬/MNI-H. He has been an Attendi ng on the Epilepsy Service at the MNI-H for more than 20 years. Dr. Hall i s fascinated by the introduction of new technology to foster novel treatme nt options. Over the past decade\, he has become interested in the strengt hs and limitations of Radio-Frequency Thermo-Coagulation via implanted ele ctrodes (SEEG) as a potential therapeutic intervention.\n\n Radio-Frequency Thermo-Coagulation via Stereoelectroencephalography\n\n This presentation will briefly review the history of Stereoelectroencephalography (SEEG) as initially proposed and the relevant advances with new materials and techni ques. For more than two decades\, commercial electrodes have been used to create lesions via Radio-Frequency Thermo-Coagulation (RF-TC). Lesion gene ration will be demonstrated ex vivo. Factors which influence lesion size a nd geometry will be discussed. Patient cases will be shown with the view t hat some pathologies underlying intractable epilepsy may be more amenable to RF-TC.\n\n  \n\n Alexander G. Weil | Epilepsy Neurosurgeon\n\n - Alexande r G. Weil\, MD\, FRCSC\, is a pediatric neurosurgeon and epilepsy surgeon at CHU Sainte-Justine and CHUM in Montreal\, and Associate Professor at th e Université de Montréal. His clinical practice is dedicated to the surgic al management of drug-resistant epilepsy in children\, with a focus on ste reo-electroencephalography (SEEG)\, resective and disconnective surgery\, and minimally invasive approaches. His research centers on epileptogenic n etworks\, connectomics\, and artificial intelligence–driven approaches to precision epilepsy surgery aimed at improving outcomes for children with c omplex epilepsy. Dr. Weil has led and collaborated on national and interna tional studies advancing epilepsy surgery and the integration of neuroimag ing\, electrophysiology\, and computational tools into clinical care.\n\n T argeting Epileptogenic Networks in Focal Cortical Dysplasia: From SEEG to Precision Surgery\n\n Focal cortical dysplasia (FCD) is one of the most com mon causes of drug-resistant focal epilepsy\, yet it is increasingly recog nized as a network disorder rather than a purely focal lesion. A network-b ased understanding of FCD is critical to improving surgical outcomes\, as the epileptogenic process often extends beyond the MRI-visible abnormality . This talk will show how stereo-electroencephalography (SEEG) helps defin e the epileptogenic network by identifying seizure onset\, propagation pat hways\, and the relationship between epileptogenic\, symptomatogenic\, and eloquent cortex. I will discuss how this framework can guide more precise resection\, disconnection\, and minimally invasive ablation\, and how adv anced connectomics can further refine individualized strategies to improve seizure freedom while minimizing functional risk.\n\n \n \n\n \n The Pierre G loor Lecture\n\n The Pierre Gloor Lecture celebrates the life and legacy of Pierre Gloor (1923–2003)\, who joined The Neuro (Montreal Neurological In stitute-Hospital) in 1952 as a fellow in electroencephalography and neurop hysiology. He trained under Wilder Penfield and Herbert Jasper and earned his PhD from ɬ﷬ in 1957. Gloor collaborated closely with cl inical and research teams at The Neuro in advancing the understanding and treatment of epilepsy\, gaining international recognition for his contribu tions to the field.\n\n Brain Mosaicism in Epilepsies and Cortical Malforma tions\n\n Speaker: Stéphanie Baulac\, PhD\n Research director and Group Lead er\n Inserm and Paris Brain Institute (ICM)\n\n Focal cortical dysplasia typ e II (FCDII) is a cortical malformation causing refractory epilepsy\, resu lting from developmental somatic mutations in mTOR pathway genes. To under stand how these mutations create a mosaic pattern of affected cells and le ad to cortical dyslamination\, we performed comprehensive single-nucleus a nalyses of surgical samples from genetically-characterized FCDII patients. By combining genotyping and transcriptomics at single-cell resolution\, w e revealed that mutations predominantly affect glutamatergic neurons and a strocytes\, creating distinct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-specific dysregulation of synaptic and neurodevelopmental pathways that likely contribute to epi leptogenesis. Notably\, our analysis of cytomegalic cells uncovered pronou nced alterations in mitochondrial metabolism pathways and cellular senesce nce. We uncover a signature associated with cellular senescence in abnorma l FCDII cells and further provide evidence in preclinical FCDII mouse mode ls that senolytic agents could offer a novel therapeutic strategy for this disorder.\n\n  \n\n \n \n\n \n Location\n\n The Montreal Neurological Institute and Hospital is at 3801 University Street\, north of Pine Avenue West\, o n the ɬ﷬ campus opposite the former Royal Victoria Hospital .\n\n Montreal is served by highway Routes 10\, 15\, 20 and 40\, and by Gre yhound Bus\, Via Rail and the P-E-Trudeau airport. In the city\, bus and m etro service is provided by the Société de transport de Montréal (STM).\n \n Wheelchair access\n\n A wheelchair accessible entrance is on University S treet north of the main entrance. Another wheelchair accessible entrance i s in the loading area behind the building: to enter the loading area\, tur n into the driveway south of the main entrance. Please note\, there is no parking in the loading area.\n\n Parking\n\n Parking near the MNI is sometim es difficult. There are parking meters on University Street and a parking lot north of the main entrance. To enter the lot\, turn right into the dri veway toward Molson Stadium.\n\n Information about parking fees\n\n Taxi Sta nd\n\n There is a taxi stand on University Street across from the main entr ance. You may call a cab from the free taxi phone in the main lobby near t he Security Desk.\n\n Access by Public Transportation (STM website)\n\n Bus \n\n There are four bus stops within walking distance:\n\n \n Bus 144 stops a t Pine Avenue and University Street\n Bus 356 stops at Sherbrooke Street an d University Street (Nightbus)\n Bus 107 stops at Pine Avenue and Docteur P enfield\n Bus 24 stops at Sherbrooke Street and University Street\n \n\n Metr o\n\n Take the Metro Green Line to the ɬ﷬ station. Walk north on Univer sity Street and cross Pine Avenue. The main entrance is on the right\, pas t the flags.\n\n Jeanne Timmins Amphitheatre\n\n \n Enter the main lobby\, tu rn left\, and go down the hallway to the end.\n Turn right and go down the second hallway until you see another hallway on the left.\n This hallway le ads to the Jeanne Timmins Foyer.\n On your right are the Jeanne Timmins Amp hitheatre entrance doors.\n \n \n\n \n Sponsors \n\n \n\n \n \n\n \n Scientific Com mittee\n\n Sam Audrain\n\n Alexander Barnett\n\n Boris Bernhardt\n\n Sara Lari vière\n\n Raluca Pana\n\n Myriam Srour\n\n  \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/dementia/channels/event/neuro-epilepsy-day-2026-e pilepsy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR