涩里番

Dr. Monzur Murshed鈥檚 training as a matrix biologist began in 1997 in the laboratory of Drs. Roswitha Nischt and Thomas Krieg at the University of Cologne, Germany, where he completed his doctoral thesis on the structure of the basal lamina, a specialized extracellular membrane with crucial biological functions.

In 2001, he joined the laboratory of Dr. Gerard Karsenty at Baylor College of Medicine in Houston, Texas, as a postdoctoral fellow, where he studied the mechanisms of extracellular matrix mineralization. During this time, he generated and analyzed several transgenic animal models to characterize the in vivo function of Matrix Gla protein (MGP), a potent mineralization inhibitor. In a separate study, he used multiple mouse models and cell culture approaches to demonstrate that bone and tooth matrix mineralization can be explained, in part, by the co-expression of broadly expressed genes. He also investigated the regulation of bone mass by the parasympathetic nervous system.

After joining 涩里番, Dr. Murshed continued his research on extracellular matrix mineralization in both hard and soft tissues. He also expanded his research interests into additional areas of bone biology, including skeletal development and the regulation of bone remodeling. Over the past fifteen years, he has worked as an extracellular matrix biologist, with twelve years dedicated specifically to biomineralization research. During this time, he has generated and analyzed numerous gene-targeted and transgenic animal models relevant to his studies. His work is currently funded by the Canadian Institutes of Health Research (CIHR) and the Heart and Stroke Foundation of Canada.