涩里番

Jerome Fortin, Assistant Professor, Department of Neurology and Neurosurgery听
Discovering how to change the fate of tumor cells to treat brain cancers听
Professor Fortin鈥檚 project seeks strategies to alter the developmental and survival pathways of tumor cells in brain cancers, with the goal of identifying new therapeutic targets for hard-to-treat brain tumors.听
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Vincent Giguere, Professor, Department of Biochemistry听
Investigating the role of the chromatin remodeler CHD4 (NuRD) in the progression of prostate cancer听
Professor Giguere will examine how the chromatin remodeling factor CHD4 and the NuRD complex influence prostate cancer progression and aim to uncover mechanisms that could be targeted to slow or stop disease progression.听
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Lawrence Kazak, Associate Professor, Department of Biochemistry
Defining mechanisms of obesity-accelerated breast cancer progression
Professor Kazak鈥檚 research focuses on the biological links between obesity and breast cancer aggressivity, aiming to identify molecular pathways that explain obesity-driven tumour progression.

Peter Siegel, Professor, Department of Medicine and Member, Rosalind and Morris Goodman Cancer Institute
Investigating a role for PDLIM7 in regulating autophagy during breast cancer metastasis
Professor Siegel will investigate how the protein PDLIM7, expressed in triple-negative breast cancer cells (TNBC), leads to TNBC metastasizing in the lungs and liver by regulating autophagy, a cellular survival process that helps cancer cells endure the stresses of metastasis. The aim is to identify the basis for new strategies to limit the ability of these aggressive cancer cells to spread.

Nahum听Sonenberg,听Distinguished James 涩里番 Professor, Department of Biochemistry and Gilman Cheney Chair, Rosalind and Morris Goodman Cancer Institute
Targeting eIF4E-mediated dysregulated mRNA translation as a therapeutic strategy for breast cancer
Professor Sonenberg will explore a new therapeutic strategy for triple-negative breast cancer by targeting dysregulated mRNA translation, a key process that fuels tumour growth. By combining a highly selective mRNA translation inhibitor with a complementary cell-cycle inhibitor, this project aims to open the door to more effective treatment options.

,听Director of the Rosalind and Morris Goodman Cancer Institute (GCI) and听Professor, Department of Microbiology and Immunology听
Targeting MFG-E8 for treatment of cancer听
Professor Stagg will investigate how MFG-E8 regulates anti-tumor immunity, and assess whether it can be targeted by antibodies for anti-cancer therapy.
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Jose Teodoro, Professor, Department of Biochemistry听
The impact of endogenous fatty acid esters of hydroxy fatty acids in colorectal cancer听
Professor 罢别辞诲辞谤辞鈥檚 project will evaluate how endogenous lipid metabolites, fatty acid esters of hydroxy fatty acids, affect colorectal cancer development and progression, and whether they can be leveraged for therapeutic benefit.听

Ian Watson, Associate Professor, Department of Biochemistry
Investigation of vesicular stomatitis virus (VSV) in the treatment of cutaneous melanoma
Professor Watson will explore the oncolytic potential of VSV as a therapeutic for cutaneous melanoma, studying its safety, tumor-targeting properties, and capacity to stimulate anti-tumor immune responses.

John White, Professor and Chair, Department of Physiology
Development and testing of novel vitamin D receptor agonist/histone deacetylase inhibitor hybrids
Professor White鈥檚 team will design and evaluate hybrid compounds that combine vitamin D receptor activation with histone deacetylase inhibition, a dual approach that may enhance anti-cancer activity and therapeutic specificity.

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