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DTSTAMP:20250802T225113Z
DESCRIPTION:Estimating the Impact of Cluster-Based Interventions: the SEARC
 H trial and HIV prevention in East Africa.\n\nDr. Laura Balzer is a Post-D
 octoral Fellow in the Department of Biostatistics at the Harvard T.H. Chan
  School of Public Health. She earned her PhD in Biostatistics from the Uni
 versity of California\, Berkeley under the guidance of Drs. Maya Petersen 
 and Mark van der Laan. Her research is on the development of optimal desig
 ns and estimators for causal effects with highly dependent data. Applicati
 ons of this work include impact evaluation for HIV prevention and treatmen
 t strategies and understanding the neighborhood determinants of health. La
 ura is also passionate about teaching more advanced causal and statistical
  methods to applied audiences. Jointly with Dr. Maya Petersen\, she was aw
 arded the 2014 ASA’s Causality in Statistics Education Award. (More info: 
 www.works.bepress.com/laura_balzer) \n\n\nEvaluation of cluster-based inte
 rventions presents significant methodological challenges. In this talk\, w
 e describe the design and analysis of the SEARCH trial\, an ongoing commun
 ity randomized trial to evaluate the impact of early HIV diagnosis and imm
 ediate treatment with streamlined care in rural Uganda and Kenya. We focus
  on 3 choices to optimize the design and analysis: pair-matching over comp
 lete randomization\, targeting the sample effect instead of a population a
 verage parameter\, and data-adaptive adjustment through a pre-specified ta
 rgeted maximum likelihood estimator (TMLE). These choices are compared the
 oretically and with finite sample simulations. We demonstrate each choice 
 improves efficiency relative to standard practice\, while maintaining nomi
 nal confidence interval coverage. We conclude with practical implications 
 and some ongoing challenges.\n
DTSTART:20161006T150000Z
DTEND:20161006T150000Z
LOCATION:Room 24\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue
  des Pins Ouest
SUMMARY:Laura B. Balzer\, Harvard T.H. Chan School of Public Health
URL:/mathstat/channels/event/laura-b-balzer-harvard-th
 -chan-school-public-health-263289
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