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UID:20260116T025743EST-9219ZKJmUJ@132.216.98.100
DTSTAMP:20260116T075743Z
DESCRIPTION:\nGrâce à la générosité des fiducies Killam\, Le Neuro convoque
  lors d’une série de séminaires des conférenciers d’exception dont les tra
 vaux passionnent ses chercheurs et ceux de l’Université ɬÀï·¬. \n\n\nPour
  participer en personne\, inscrivez-vous ici\n\nPour visionner la diffusio
 n sur Vimeo\, cliquez sur le lien suivant\n\n\nIain Clark\n\nProfesseur ad
 joint\, bio-ingénierie\, UC Berkeley\, États-Unis\n\nHôte: jo.stratton [at
 ] mcgill.ca (Jo Anne Stratton)\n\nAbstract: Central nervous system (CNS)-r
 esident astrocytes and microglia interact to regulate pro-inflammatory pro
 grams that drive neurodegenerative diseases\, but the pathways and molecul
 es involved are largely unknown. Understanding the language of inflammatio
 n is a central question in the field of Neuroimmunology and may guide new 
 therapeutic approaches for multiple sclerosis (MS) and other neurologic di
 seases. Interactions between CNS-resident cells are highly heterogeneous\;
  astrocytes and microglia nourish and protect neurons\, while inflammatory
  subsets drive demyelination and neurodegeneration in neurologic diseases.
  We recently developed two novel approaches to study astrocyte-microglia i
 nteractions at the single-cell level during inflammation: 1) an in vivo ba
 rcoding-based strategy that analyzes the transcriptomes and connections be
 tween individual cells\, and 2) a droplet-based platform for genome-wide\,
  unbiased CRISPR/Cas9 screening of genes that mediate cell crosstalk. In t
 his seminar\, I will discuss the development of these technologies and the
 ir application to study astrocyte-microglia signaling in experimental auto
 immune encephalomyelitis (EAE)\, a preclinical mouse model of MS.\n
DTSTART:20240220T210000Z
DTEND:20240220T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Microfluidic tools for studying cell-cell in
 teractions 
URL:/neuro/fr/channels/event/killam-seminar-series-mic
 rofluidic-tools-studying-cell-cell-interactions-353656
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