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BEGIN:VEVENT
UID:20250810T184819EDT-3759iUxoHv@132.216.98.100
DTSTAMP:20250810T224819Z
DESCRIPTION:\nGrâce à la générosité des fiducies Killam\, Le Neuro convoque
  lors d’une série de séminaires des conférenciers d’exception dont les tra
 vaux passionnent ses chercheurs et ceux de l’Université ɬÀï·¬. \n\n\nPour
  participer en personne\, inscrivez-vous ici\n\nPour visionner la diffusio
 n sur Vimeo\, cliquez sur le lien suivant\n\n\nHelen Bateup\, PhD\n\nProfe
 sseure associée\, Département de biologie moléculaire et cellulaire\, UC B
 erkely\, États-Unis\n\nHôte: j-francois.poulin [at] mcgill.ca (Jean-Franço
 is Poulin)\n\nAbstract: Dopamine neurons represent a small fraction of neu
 rons in the brain\, yet they exert widespread influence over a variety of 
 brain systems that control motor function\, reward\, motivation\, and lear
 ning. Recent work from our lab and others has uncovered considerable diver
 sity within the dopaminergic system\, which likely underlies its pleotropi
 c functions. Importantly\, dysfunction of different classes of dopamine ne
 urons contribute to neuropsychiatric and neurodegenerative disorders. In t
 his talk\, I will present our work investigating the molecular pathways th
 at regulate dopaminergic function. In particular\, I will discuss our find
 ings showing that mTOR\, a central regulator of cell growth and metabolism
 \, is a key modulator of dopamine neuron structure and function. I will pr
 esent data from mouse models showing that balanced mTOR activity is critic
 al for proper dopaminergic output\, as suppression or overactivation of mT
 OR has detrimental effects on multiple aspects of dopamine neuron biology.
  In addition\, I will discuss our ongoing collaborative work to investigat
 e the pathways that contribute to dopamine neuron degeneration in the cont
 ext of Parkinson’s disease\, using functional genomics approaches in human
  midbrain organoids.\n
DTSTART:20240416T200000Z
DTEND:20240416T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Molecular Mechanisms Controlling Dopamine Ne
 uron Biology in Health and Disease
URL:/neuro/fr/channels/event/killam-seminar-series-mol
 ecular-mechanisms-controlling-dopamine-neuron-biology-health-and-disease-3
 55150
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