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DTSTAMP:20260224T063136Z
DESCRIPTION:The iPSC Seminar Series at The Neuro\n\nSupported by Healthy Br
 ains for Healthy Lives and STEMCELL Technologies\, The Neuro’s iPSC Semina
 r Series welcomes trainees and senior scientists working with induced plur
 ipotent stem cells (iPSCs) to present their cutting-edge research. The Sem
 inar Series intends to foster collaborations within the network of laborat
 ories working with iPSCs in Montreal\, Canada and around the world.\n\nIf 
 you\, or someone you know\, would be interested in presenting please conta
 ct us to secure a spot on the schedule.\n\nTo register:  Eventbrite\n\n\nS
 peaker : Martin Berryer\, PhD\n\nThe Broad Institute of Harvard and MIT\, 
 USA\n\nTalk : Automated High-Throughput Synaptic Screen in Human Induced N
 eurons\n\nThe synapse is a fundamental point of communication in the nervo
 us system\, and deeper insight into synaptic mechanisms is critical for ou
 r understanding of normal brain function as well as dysfunction in develop
 mental and degenerative diseases. While diverse brain cell types can now b
 e generated from human pluripotent stem cells in vitro\, knowledge of huma
 n synaptogenesis remains incomplete. We therefore developed a novel and sc
 alable assay for automated high-content quantification of synaptic develop
 ment in vitro using human neurons and astrocytes. We employed this phenoty
 pic screening strategy to uncover modulators of human synaptogenesis from 
 a small molecule library and successfully identified a set of diverse comp
 ounds that increase the synaptic network connectivity in human neural co-c
 ulture. Our results demonstrate the power of phenotyping assay in human ne
 urons derived from pluripotent stem cells and provide a robust platform fo
 r the interrogation of neuronal connectivity in developmental and degenera
 tive diseases. \n
DTSTART:20220127T210000Z
DTEND:20220127T220000Z
SUMMARY:iPSC Seminars: Early Drug Discovery Unit (EDDU) (Virtual)
URL:/neuro/channels/event/ipsc-seminars-early-drug-dis
 covery-unit-eddu-virtual-333040
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