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DTSTAMP:20250805T210845Z
DESCRIPTION:The Killam Seminar Series presents 'mTOR Signaling and Choleste
 rol Biosynthesis define Oligodendroglial Heterogeneity between Brain and S
 pinal Cord'\n\nThe seminar will be taking place in person at The Neuro (De
  Grandpre Communications Center)\n\nTo attend in person\, register here.\n
 \nTo attend virtually\, register here.\n\nSpeaker: Teresa (Terri) Wood\, P
 hD\n\nDistinguished Professor and Rena Warshow Endowed Chair in Multiple S
 clerosis\n\nDepartment of Pharmacology\, Physiology & Neuroscience and Cen
 ter for Cell Signaling\n\nNew Jersey Medical School\, Rutgers University\,
  USA\n\nAbstract: Brain and spinal cord oligodendroglia have distinct func
 tional characteristics\, and cell-autonomous loss of individual genes such
  as the mechanistic target of rapamycin (mTOR) result in different regiona
 l phenotypes. However\, a molecular basis for these distinctions is unknow
 n. I will present our findings using single-cell analysis of oligodendrogl
 ia during developmental myelination demonstrating that brain and spinal co
 rd precursors are transcriptionally distinct\, defined predominantly by ch
 olesterol biosynthesis. We further identified mTOR as a major regulator pr
 omoting cholesterol biosynthesis in oligodendroglia. mTOR loss in spinal c
 ord oligodendroglia has a greater impact on cholesterol biosynthesis\, con
 sistent with more pronounced deficits in developmental myelination. In the
  brain\, mTOR loss results in a later adult myelin deficit\, including oli
 godendrocyte death\, spontaneous demyelination\, and impaired axonal funct
 ion\, demonstrating that mTOR is required for myelin maintenance in the ad
 ult brain. I will also present data on functions for upstream (TSC) and do
 wnstream (p70S6K) mediators of mTOR signaling in developmental myelination
  and adult myelin maintenance.\n\nBio: Dr. Wood is a Distinguished Profess
 or in the Department of Neurology and Neuroscience at NJMS. She holds the 
 Rena Warshow Endowed Chair in Multiple Sclerosis. Dr. Wood is a 1978 gradu
 ate of Carleton College in Northfield\, Minnesota. She completed her Ph.D.
  in Molecular Neurobiology in 1987 at UCLA followed by post-doctoral studi
 es first at the State University of New York (Stony Brook)\, in the Depart
 ment of Neurobiology and Behavior and then at Columbia University\, Depart
 ment of Anatomy and Cell Biology. Her academic career includes 12 years on
  the faculty of the Pennsylvania State University College of Medicine in H
 ershey\, PA. Dr. Wood joined the New Jersey Medical School (NJMS) faculty 
 in 2005 which became part of Rutgers University in 2015.\n\nDr. Wood’s res
 earch has benefited from 25 years of continuous funding from the National 
 Institutes of Health including a current Javits Neuroscience Investigator 
 Merit Award from the National Institutes of Neurological Disorders and Str
 oke. She has also had funding from the National Multiple Sclerosis Society
 \, the Department of Defense and the American Cancer Society. Dr. Wood is 
 the recent past-President of the American Society for Neurochemistry. In 2
 019\, she received the honor of being elected a fellow in the AAAS for “he
 r research on growth factors and their signaling pathways as they pertain 
 to stem cell differentiation\, cancer\, and neurodegenerative diseases.” D
 r. Wood was also promoted to Distinguished Professor at Rutgers University
  in 2020. One of her main passions in science has been in training the nex
 t generation of scientists. She has mentored numerous students through the
 ir PhDs\, has directed graduate programs at both PSU and NJMS\, Rutgers Un
 iversity\, and currently directs the required PhD course in Professional S
 kills: Grant Writing.\n\n\nSupported by the generosity of the Killam Trust
 s \, The Neuro’s Killam Seminar series hosts outstanding guest speakers.\n
DTSTART:20220621T200000Z
DTEND:20220621T210000Z
SUMMARY:Killam Seminar Series: mTOR Signaling and Cholesterol Biosynthesis 
 define Oligodendroglial Heterogeneity between Brain and Spinal Cord
URL:/neuro/channels/event/killam-seminar-series-mtor-s
 ignaling-and-cholesterol-biosynthesis-define-oligodendroglial-339914
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