BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20251109T142021EST-1671VJKu7U@132.216.98.100 DTSTAMP:20251109T192021Z DESCRIPTION:\nTo attend in person\, register here.\n\nTo watch via vimeo\, click here.\n\n\nMark Nelson\n\nDistinguished Professor\, Pharmacology\, U niversity of Vermont\, USA\n\n\nAbstract: The Nelson laboratory's research interests include elucidating the mechanisms by which cerebral blood flow is controlled to meet the diverse and ever-changing demands of active neu rons and how these mechanisms are disrupted in small vessel disease (SVD)- a major cause of stroke and dementia. Dr. Nelson and colleagues have unrav eled many of the major mechanisms that control cerebrovascular function\, including the discovery of local calcium signals ('sparks')\, which counte r-intuitively oppose vasoconstriction. They have recently shown that brain capillaries act as a neural activity-sensing network by initiating and tr ansmitting an electrical signal\, mediated by potassium channel activation \, that propagates through the interconnected endothelial cells comprising the capillaries that line all blood vessels. This concept explains the ra pid and coordinated delivery of blood to active neurons. Using a mouse mod el of a monogenic form of SVD\, they have discovered early defects that re sult in a loss of this electrical signaling mechanism and impaired deliver y of blood to active neurons-defects that involve changes in extracellular matrix composition. The near-term goals of Nelson laboratory researchers are to create an integrated view of electrical\, calcium and related regul atory signaling mechanisms at molecular\, biophysical\, and computational- modeling levels by examining their operation in increasingly complex segme nts of the brain vasculature ex vivo\, in vivo\, and in silico. Ultimately \, they propose to weave these research threads together to create a syste ms-level view of physiological signaling in the brain microcirculation\, a nd test the concept that gradual degradation of this sensory web and the a ttendant progressive decay of cerebrovascular function contributes to SVDs of the brain\n\nBio: Mark T. Nelson is an internationally recognized lea der in the study of vascular smooth muscle\, calcium signaling and ion cha nnels. He received his B.S. in Mathematics and Biology from Tufts Universi ty with honors\, and his Ph.D. in Neural Sciences from Washington Universi ty\, St. Louis\, MO. He was recruited to the University of Vermont in 1986 and promoted to full professor in 1992. Dr. Nelson has served as Chair of the Pharmacology Department since 1996\, and was honored in 2009 as a Uni versity Distinguished Professor. Since 2006\, he has been a part-time Prof essor at the University of Manchester\, UK\, and since 2012 as a Visiting Professor at the University of Oxford\, UK. Dr. Nelson is a member of the National Academy of Sciences.\n\nMark Nelson is a member of the NIDDK Advi sory Council. His work has been recognized by the NIH with over thirty yea rs of continuous funding\, an NIH Merit Award\, an NIH Outstanding Investi gator Award\, and with funding from Fondation Leducq and the European Unio n.\n\nHe serves on Editorial Boards for Proceedings of the National Academ y of Sciences\, eLife\, Journal of General Physiology\, and as co-editor f or Annual Reviews of Physiology. Dr. Nelson has produced over 270 publicat ions in high quality\, peer reviewed journals\, and mentored sixty postdoc s and research faculty members.\n\n\nSupported by the generosity of the Ki llam Trusts\, the MNI's Killam Seminar Series invites outstanding guest sp eakers whose research is of interest to the scientific community at the MN I and ɬÀï·¬.\n DTSTART:20230228T210000Z DTEND:20230228T220000Z LOCATION:De Grandpré Communications Centre\, Montreal Neurological Institut e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University SUMMARY:Killam Seminar Series: The Shadow Nervous System: A look into brain capillaries when they work and don’t URL:/neuro/channels/event/killam-seminar-series-shadow -nervous-system-look-brain-capillaries-when-they-work-and-dont-342340 END:VEVENT END:VCALENDAR