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UID:20251110T091044EST-5130G6ZTUv@132.216.98.100
DTSTAMP:20251110T141044Z
DESCRIPTION:To attend in person\, register here.\n\nTo watch via vimeo\, cl
 ick here.\n\n\nLarry Zweifel\n\nProfessor\, Psychiatry\, University of Was
 hington\, USA\n\nHost: Jean-Francois Cloutier\n\n\nAbstract: Dopamine prod
 ucing neurons of the ventral midbrain play an essential role in regulating
  reinforcement learning and motivation. Numerous neurotransmitters and neu
 ropeptides regulate the function of midbrain dopamine neurons\, but how th
 ese transmitters and peptides coordinate to optimize the function of dopam
 inergic cells is not well resolved. I will describe our efforts to map the
  sources of neurotransmitters and neuropeptides to the ventral midbrain an
 d to define the genetic heterogeneity of cell types within this brain regi
 on. I will discuss how viral delivery of the CRISRP/Cas9 system to specifi
 c cell types can be used to resolve the function of specific neurotransmit
 ter and neuropeptide inputs to the ventral midbrain and the functionality 
 of specific neuropeptide-associated signaling pathways in the modulation o
 f dopamine neuron function.\n\nBio: The main focus of my research efforts 
 are to define how specific genes influence neuronal connectivity and funct
 ion within neural circuits that regulate innate and motivated behaviors wi
 th a special emphasis on genes linked to psychiatric disorders such as sch
 izophrenia and depression.\n\nMy laboratory utilizes conventional mouse ge
 netics approaches coupled to viral-based strategies for projection specifi
 c gene manipulation\, optogenetic and pharmacogentic approaches\, in vivo 
 single unit electrophysiology recordings\, whole-cell patch clamp\, in viv
 o fiber-optic imaging\, and behavior. We have recently demonstrated that a
  disease-related mutation in the human KCNN3 gene that encodes the calcium
  activated potassium channel SK3 significantly alters activity pattern reg
 ulation of midbrain dopamine neurons resulting in disruption of specific b
 ehavioral domains relevant to schizophrenia.\n\nWe have also shown that ph
 asic activation of dopamine neurons potently influences fear processing by
  the amygdala and is critical for the prevention of generalized fear and a
 nxiety. Other recent developments in the lab include the identification of
  CRF neurons in the central amygdala as key regulators of cued fear memory
  acquisition and the identification of a novel dopaminergic pathway within
  the hypothalamus that regulates social behavior\n\n\nSupported by the gen
 erosity of the Killam Trusts\, the MNI's Killam Seminar Series invites out
 standing guest speakers whose research is of interest to the scientific co
 mmunity at the MNI and ɬÀï·¬.\n
DTSTART:20230307T210000Z
DTEND:20230307T220000Z
LOCATION:De Grandpré Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Resolving the neuropeptide modulation of the
  midbrain dopamine system
URL:/neuro/channels/event/killam-seminar-series-resolv
 ing-neuropeptide-modulation-midbrain-dopamine-system-342342
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