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UID:20251110T091157EST-1247Pcogvr@132.216.98.100
DTSTAMP:20251110T141157Z
DESCRIPTION:**The Killam Seminar on May 2 has been postponed to a later dat
 e.\n\nTo attend in person\, register here.\n\nTo watch via vimeo\, click h
 ere.\n\n\nJeremy Dittman\n\nAssociate Professor\, Biochemistry\, Weill Cor
 nell Medicine\, United States\n\nHost: Wayne Sossin\n\nAbstract: Munc13 is
  a deeply conserved synaptic hub protein that coordinates nearly every asp
 ect of neurotransmitter release\, although we still lack a mechanistic und
 erstanding of its actions at the synapse. Using a forward genetic screen i
 n C. elegans\, we identified and characterized a unique C-terminal domain 
 that is critical for maintaining the pool of fusion-competent vesicles at 
 the synapse (the docking/priming function of Munc13). We also determined t
 hat a neighboring protein module comprising a C1-C2 tandem domain mediates
  an autoinhibitory function that is critical for proper regulation of syna
 ptic transmission. A human point mutation in this site leads to severe neu
 rological dysfunction due to a gain of Munc13 activity. Together with rece
 nt structural work on Munc13\, our biochemical\, genetic\, and physiologic
 al data suggest a principal organizational role for Munc13 in controlling 
 vesicle docking\, SNARE assembly\, and membrane fusion.\n\nBio: The long-t
 erm goal of our research is to elucidate the molecular mechanisms that und
 erlie both the plasticity and stability of synapses. Synapses are the site
 s of communication between the individual cells of the brain\, and these s
 pecial connections can be altered by experience\, development\, and diseas
 e. Our lab studies several highly conserved molecules involved in synaptic
  transmission using cutting-edge imaging and molecular techniques combined
  with biochemical\, physiological\, and biophysical assays in the nematode
  C. elegans as a model system. C. elegans has proven to be a powerful gene
 tic model for the study of essential neuronal proteins because of its amen
 ability to molecular manipulation\, fluorescent and electron micrographic 
 imaging\, physiological and pharmacological assays\, and its simple geneti
 cs.\n\n\nSupported by the generosity of the Killam Trusts\, the MNI's Kill
 am Seminar Series invites outstanding guest speakers whose research is of 
 interest to the scientific community at the MNI and ɬÀï·¬.\n
DTSTART:20230502T200000Z
DTEND:20230502T210000Z
LOCATION:De Grandpré Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:POSTPONED: Killam Seminar Series: Importance of Munc13 in synaptic 
 transmission:  New Mechanistic Insights into an Old Problem
URL:/neuro/channels/event/postponed-killam-seminar-ser
 ies-importance-munc13-synaptic-transmission-new-mechanistic-insights-old-3
 42351
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