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UID:20251110T091122EST-3468UkiWJw@132.216.98.100
DTSTAMP:20251110T141122Z
DESCRIPTION:Supported by the generosity of the Killam Trusts\, the MNI's Ki
 llam Seminar Series invites outstanding guest speakers whose research is o
 f interest to the scientific community at the MNI and ɬŔď·¬.\n
 \n\nTo attend in person\, register (here)\n\nTo watch virtually\, click (h
 ere)\n\n\nLaura Airas\, PhD\n\nProfessor of Neuroimmunology\, University o
 f Turku\, Finland\n\nHost: Roberta La Piana\n\nAbstract: Microglia normall
 y protects the central nervous system (CNS) against insults. However\, the
 ir persistent activation in multiple sclerosis (MS) contributes to injury.
  In my talk I will discuss microglia activation in MS and their detection 
 using positron emission tomography (PET). During lesion evolution and the 
 progression of MS\, microglia activity may contribute to neurotoxicity thr
 ough the release of pro-inflammatory cytokines\, reactive oxidative specie
 s\, proteases and glutamate. A means to detect and monitor microglia activ
 ation in individuals living with MS is provided by PET imaging using the m
 itochondrial 18-kDa translocator protein (TSPO) ligand. TSPO PET imaging s
 hows increased microglial activation both within the normal appearing whit
 e matter and at the edge of chronic lesions. PET-detected microglia activa
 tion increases with progression of MS. These findings demand the use of CN
 S penetrant inhibitors that affect microglia. Such therapies may include h
 ydroxychloroquine that is recently reported in a small study to reduce the
  expected progression in primary progressive MS\, and Bruton’s tyrosine ki
 nase inhibitors for which there are now eleven Phase 3 registered trials i
 n MS.\n
DTSTART:20231003T200000Z
DTEND:20231003T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Microglia in Multiple Sclerosis - Pathogenes
 is and Imaging
URL:/neuro/channels/event/killam-seminar-series-microg
 lia-multiple-sclerosis-pathogenesis-and-imaging-350909
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