BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250817T205213EDT-7167gNcIFd@132.216.98.100
DTSTAMP:20250818T005213Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at the MNI and ɬÀï·¬ Universit
 y.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, click 
 here\n\n\nIain Clark\n\nAssistant Professor\, Bioengineering\, UC Berkeley
 \, USA\n\nHost: jo.stratton [at] mcgill.ca (Jo Anne Stratton)\n\nAbstract:
  Central nervous system (CNS)-resident astrocytes and microglia interact t
 o regulate pro-inflammatory programs that drive neurodegenerative diseases
 \, but the pathways and molecules involved are largely unknown. Understand
 ing the language of inflammation is a central question in the field of Neu
 roimmunology and may guide new therapeutic approaches for multiple scleros
 is (MS) and other neurologic diseases. Interactions between CNS-resident c
 ells are highly heterogeneous\; astrocytes and microglia nourish and prote
 ct neurons\, while inflammatory subsets drive demyelination and neurodegen
 eration in neurologic diseases. We recently developed two novel approaches
  to study astrocyte-microglia interactions at the single-cell level during
  inflammation: 1) an in vivo barcoding-based strategy that analyzes the tr
 anscriptomes and connections between individual cells\, and 2) a droplet-b
 ased platform for genome-wide\, unbiased CRISPR/Cas9 screening of genes th
 at mediate cell crosstalk. In this seminar\, I will discuss the developmen
 t of these technologies and their application to study astrocyte-microglia
  signaling in experimental autoimmune encephalomyelitis (EAE)\, a preclini
 cal mouse model of MS.\n
DTSTART:20240220T210000Z
DTEND:20240220T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Microfluidic tools for studying cell-cell in
 teractions 
URL:/neuro/channels/event/killam-seminar-series-microf
 luidic-tools-studying-cell-cell-interactions-353656
END:VEVENT
END:VCALENDAR