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UID:20250805T214229EDT-7512zNOCeU@132.216.98.100
DTSTAMP:20250806T014229Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and ɬÀï·¬ Univers
 ity.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, clic
 k here\n\n\nFranck Polleux\n\nProfessor of Neuroscience\, Columbia Univers
 ity\n\nHost: eric.shoubridge [at] mcgill.ca (Eric Shoubridge )\n\nAbstract
 : Two of the most striking distinguishing features of human cortical pyram
 idal neurons (CPNs) are: (1) human CPNs receive significantly more excitat
 ory and inhibitory synapses than any other mammalian species including non
 -human primates and (2) synaptic development is strikingly neotenic in hum
 ans\, taking years to reach maturation compared to weeks or months in othe
 r mammalian species. Our lab identified two human-specific gene duplicatio
 ns called SRGAP2B/C which\, by inhibiting all known functions of the post-
 synaptic ancestral protein SRGAP2A\, leads to slower (neotenic) rates of e
 xcitatory (E) and inhibitory (I) synaptic maturation and increased E and I
  synapse number. We also demonstrated that this increased density of E syn
 apses in layer 2/3 cortical pyramidal neurons (CPNs) originates from incre
 ased cortico-cortical connections\, leading to changes in the coding prope
 rties of these neurons in vivo and improved behavioral performance in a se
 nsory discrimination task in mice humanized for SRGAP2C expression. I will
  summarize recent results demonstrating (1) the function of human-specific
  genes SRGAP2B/C as critical modifiers of synaptic development in human ne
 urons using xenotransplantation and (2) that SRGAP2B/C also act as human-s
 pecific disease modifiers in the context of neurodevelopmental disorders.
 \n
DTSTART:20241112T210000Z
DTEND:20241112T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Human-Specific Modifiers of Cortical Circuit
 s Evolution
URL:/neuro/channels/event/killam-seminar-series-human-
 specific-modifiers-cortical-circuits-evolution-359673
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