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DTSTAMP:20250920T161006Z
DESCRIPTION:BIERMAN'S GUEST LECTURE\n\nPlasticity of cancer invasion\, meta
 stasis and therapy response\n\nCancer invasion and metastasis arise from a
  multi-step program of tissue penetration by single cell or collective inv
 asion\, which depend on coordination of cell shape\, deformability and act
 in dynamics relative to the tissue environment. We applied a multi-scale a
 pproach of intravital multiphoton second and third harmonic generation and
  fluorescence microscopy\, 3D electron microscopy and targeted therapy to 
 identify the key steps of invasion\, metastatic escape and cross-talk of i
 nvasion programs with therapy resistance. As main routes\, non-destructive
  contact-guidance is mediated by preformed multi-interface 1D\, 2D and 3D 
 tissue topologies [1]. This results in adaptive cancer cell responses and 
 programming of collective invasion modes\, either as multicellular dynamic
  networks\, or as compact multicellular invasion strands [2]. For collecti
 ve invasion\, the invasion pattern includes a range of cell-cell interacti
 on mechanisms\, including adherens junctions\, gap junctions and yet uncle
 ar low-adhesive interactions supported by high cell density and tissue con
 finement [1\, 2]. 3D ultrastructural analysis reveals predefined tissue co
 nduits (“highways”) of defined geometry\, nanotropography and molecular co
 mposition or complex interstitial networks of collagen fibers or astrocyti
 c structures as predominant routes of invasion. Invasion niches mediated r
 esistance to radiation therapy\, and multi-targeted interference against b
 eta1/alphaV/beta3/beta5 integrins\, but not single-targeted therapy\, erad
 icated the resistance niche [3]. In conclusion\, cancer invasion is mainta
 ined by physicochemical programs that balance cell-intrinsic adhesion and 
 mechanocoupling with encountered physical space and molecular cues which c
 ross-talk to therapy resistance.\n\n1. Van Helvert S\, Storm C\, Friedl P.
  Mechanoreciprocity of cell migration. Nat Cell Biol\, 20\, 8-20\, 2018.\n
 \n2. Gritsenko PG\, Atlasy N\, Dieteren CEJ\, Navis AC\, Venhuizen J-H\, V
 eelken C\, Schubert D\, Acker-Palmer A\, Westerman BA\, Wurdinger T\, Leen
 ders W\, Wesseling P\, Stunnenberg HG\, Friedl P. (2020) P120-catenin depe
 ndent collective brain infiltration by glioma-cell networks. Nat Cell Biol
 \, 22(1):97-107.\n\n3. Haeger A\, Alexander S\, Vullings M\, Kaiser FMP\, 
 Veelken C\, Flucke U\, Koehl GE\, Hirschberg M\, Flentje M\, Hoffman RM\, 
 Geissler EK\, Kissler S\, Friedl P Collective cancer invasion forms an int
 egrin-dependent radioresistant niche. J Exp Med 217(1). pii: e20181184\, 2
 020\n\nThis lecture will be given online via Zoom. Details in attached pos
 ter.\n\n__________________________________________________________________
 ___________\n\nDr. Friedl was born and raised in Germany\, received his M.
 D. degree from the University of Bochum in 1992 and the Ph.D. degree from 
 the ɬ�﷬\, Montreal in 1996. Since 2007 he is directing the M
 icroscopical Imaging Centre of the Radboud University Nijmegen Medical Cen
 tre\, Nijmegen\, Netherlands and since 2011 holds a joint-faculty position
  at the University of Texas MD Anderson Cancer Center\, Houston\, TX for p
 reclinical intravital imaging of cancer lesions and their response to mole
 cular targeted and immunotherapy. His research interest is the mechanisms 
 and plasticity of cell migration in immune regulation and cancer metastasi
 s\, with emphasis on cell-matrix adhesion\, pericellular proteolysis and c
 ell-cell communication during migration.\n\nHis laboratory identified path
 ways determining diversity and plasticity of cell migration\, collective c
 ancer cell invasion\, and the contribution of migration pathways to immune
  defense and cancer resistance. His discoveries have provided a nomenclatu
 re for the different types of cell migration and their roles in building a
 nd (re)shaping tissue\, with emphasis on inflammation\, regeneration and c
 ancer. His therapeutic preclinical studies focus on the intravital visuali
 zation of niches and mechanisms and strategies to overcome therapy resista
 nce.\n
DTSTART:20210514T193000Z
DTEND:20210514T203000Z
SUMMARY:26th Annual Graduate Research Day 
URL:/physiology/channels/event/26th-annual-graduate-re
 search-day-302594
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