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UID:20260119T112934EST-5558iCNOO5@132.216.98.100
DTSTAMP:20260119T162934Z
DESCRIPTION:This seminar has been cancelled.\n\nThe human naive T-cell rece
 ptor (TCR) repertoire is extremely diverse and accurately estimating its d
 istribution is challenging. We address this challenge by combining a quant
 itative sequencing protocol of TCRA and TCRB sequences with computational 
 modeling. We observed the vast majority of TCR chains only once in our sam
 ples\, confirming the enormous diversity of the naive repertoire. However\
 , a substantial number of sequences were observed multiple times within sa
 mples\, and we confirmed that this was due to high abundance in the naive 
 pool\, rather than high mRNA levels. We reason that alpha and beta chains 
 become abundant due to a combination of selective processes and summation 
 over multiple clones expressing these chains. We test the contribution of 
 both mechanisms by predicting samples from phenomenological and mechanisti
 cally modeled repertoire distributions. By comparing these with sequencing
  data\, we show that most abundant chains are likely to be derived from mu
 ltiple clones. Still\, a neutral model of T-cell homeostasis cannot accoun
 t for the observed distributions. We conclude that the data are only compa
 tible with distributions of many small clones in combination with a suffic
 ient number of very large naive T-cell clones\, most likely as a result of
  strong peripheral selection.\n\nThis event is part of the Physiology Frid
 ay Seminar Series and is co-sponsored by CAMBAM.\n
DTSTART:20200320T150000Z
DTEND:20200320T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:SEMINAR CANCELLED
URL:/physiology/channels/event/seminar-cancelled-30862
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