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UID:20250809T134545EDT-5072uMoKFO@132.216.98.100
DTSTAMP:20250809T174545Z
DESCRIPTION:Intestinal helminths remain one of the most pervasive parasites
  of the animal kingdom by stimulating host defense pathways that prioritiz
 e tissue adaptation over parasite expulsion. Although helminths form intim
 ate interactions with the intestinal epithelium\, their ability to directl
 y shape the fate of this barrier cell type is unknown. Here we show that i
 nfection of mice with Heligmosomoides polygyrus bakeri (Hpb) induces a fet
 al reprogramming of the intestinal epithelial cell niche coincident with a
 dult parasite adherence to intestinal villi. This reprogramming event was 
 characterized by a regenerative Hippo pathway transcriptional signature an
 d the emergence of Clusterin-expressing ‘revival’ stem cells (revSC) previ
 ously shown to drive intestinal repair following acute injury. Furthermore
 \, lineage tracing studies confirmed the presence of revSC-derived progeny
  along the villi of Hpb-colonized animals. Remarkably\, intestinal organoi
 ds exposed to Hpb excretory-secretory products rapidly assumed a spheroid 
 morphology and expressed a fetal gene battery\, a phenotype associated wit
 h gut organogenesis. By contrast\, interleukin-13 inhibited revSC developm
 ent in vitro while deletion of type 2 cytokine signaling in vivo led to an
  enhanced fetal host response and increased worm fitness. Collectively\, o
 ur study reveals how a helminth parasite co-opts a tissue development prog
 ram to counter type 2 immune-mediated expulsion and maintain chronic infec
 tion.\n\nThis seminar will be given online via Zoom. Details in attached p
 oster.\n
DTSTART:20210409T150000Z
DTEND:20210409T160000Z
SUMMARY:Online Seminar - Type 2 immunity vs helminths: Tales from the crypt
URL:/physiology/channels/event/online-seminar-type-2-i
 mmunity-vs-helminths-tales-crypt-328708
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