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UID:20250805T045726EDT-8604RhtUEK@132.216.98.100
DTSTAMP:20250805T085726Z
DESCRIPTION:The beneficial effects of infection and the ensuing inflammatio
 n on neurological disorders have previously been noted. For example\, a su
 bset of children with autism spectrum disorder (ASD) exhibits temporary bu
 t considerable improvements in their behavioral symptoms during episodes o
 f fever\, a sign of systemic inflammation. However\, a mechanistic underst
 anding of how fever-associated immune responses translate into behavioral 
 relief—both at the molecular and neural level—is lacking. We show that the
  social behavioral deficits in offspring exposed to maternal immune activa
 tion can be temporarily rescued by the inflammatory response elicited by t
 he administration of lipopolysaccharide (LPS). This behavioral rescue was 
 accompanied by a reduction in neural activity in the primary somatosensory
  cortex dysgranular zone (S1DZ)\, the hyperactivity of which has previousl
 y been implicated in the manifestation of behavioral phenotypes associated
  with offspring exposed to MIA. We also show that both the behavioral resc
 ue and the reduction in neural activity are mediated through the expressio
 n of IL-17 receptor subunit a (IL-17Ra) in the neurons of the S1DZ.\n\nThi
 s seminar will be given online via Zoom. Details in attached poster.\n
DTSTART:20210430T150000Z
DTEND:20210430T160000Z
SUMMARY:Online Seminar - Neuroimmune Interactions Shaping Social Behavior
URL:/physiology/channels/event/online-seminar-neuroimm
 une-interactions-shaping-social-behavior-329633
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