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DTSTAMP:20250511T193833Z
DESCRIPTION:Nedergaard is a pioneer in the field of neuroglial signaling. S
 he was the first to show that astrocytes can transmit calcium signals to n
 eurons\; that astrocytes regulate inhibitory neurotransmission\; that they
  communicate by purinergic signaling\; that they in live brain are activat
 ed by sensory stimulation\; and that they regulate cerebral perfusion. Ned
 ergaard also showed that astrocytes control the extracellular ion composit
 ion and thereby by a simple\, yet powerful mechanism\, can control neural 
 circuit activity. Her collaborative studies revealed that the size and com
 plexity of astrocytes increases across phylogeny\, and that engraftment of
  human astrocytes enhances the cognitive performance of mice. Clinically-t
 rained\, she has identified a role of astrocytic pathology in spinal cord 
 injury\, epilepsy\, ammonium toxicity\, glioma invasion and activation of 
 astrocytes in deep brain stimulation. Yet\, her notable discovery is of th
 e (glia-lymphatic) glymphatic system\, a brain-wide fluid clearance system
 . She showed that the glymphatic system is activated during sleep and clea
 rs waste metabolites. Glymphatic transport declines in aging\, chronic dis
 eases\, and sleep disturbances\, thus linking its failure to an increased 
 risk of dementing illness.\n\nHer most recent work has highlighted glympha
 tic transport as the basis for acute post-ischemic cerebral edema\, a reve
 lation that has breathed new life into modern therapeutic approaches. In s
 um\, Nedergaard’s work has revealed that astrocytes are active participant
 s in higher brain function and critical causal contributors to brain disea
 se\, while laying out clear paths to fundamentally new therapeutic avenues
  going forward.\n\nThe image above shows glymphatic CSF delivery of an ant
 ibody (green) directed against amyloid-b binding amyloid plaques (blue). T
 he vasculature is labeled with red. \n\nThis talk will take place virtuall
 y. Full event details TBA.\n\n \n\n \n
DTSTART:20220513T193000Z
DTEND:20220513T203000Z
SUMMARY:27th Annual Graduate Research Day: The Glymphatic System
URL:/physiology/channels/event/27th-annual-graduate-re
 search-day-glymphatic-system-337007
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