BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250813T153110EDT-35060ITFwb@132.216.98.100
DTSTAMP:20250813T193110Z
DESCRIPTION: \n\nThe development of effective therapeutic strategies for Al
 zheimer`s disease (AD) must take into consideration the ample spectrum of 
 this disease\, which has been associated with changes in a wide range of n
 etworks including neurotransmitter systems\, neurotrophic factors\, immune
  system\, neuroendocrine system\, and epigenetics. We have been investigat
 ing the influence of the periphery-to-brain communication in health and di
 sease\, with a focus in AD. Our studies focus on the understanding of mech
 anisms by which defective hormonal signaling favors AD and how physical ex
 ercise may slow down AD progression and bring about positive outcomes for 
 patients. We recently showed that FNDC5/irisin\, an hormone produced by th
 e muscle upon exercise\, is decreased in AD brains. FNDC5/irisin corrects 
 synapse and memory defects in AD mouse models and was found to mediate the
  beneficial effects of exercise in memory in mice. Our study indicates the
  existence of an interesting muscle-brain axis. Determination of physical 
 exercise protocols capable of modulating the muscle-brain axis in humans c
 an lead to optimized strategies to preserve overall brain health and cogni
 tion.\n\n Details in attached poster\n
DTSTART:20230210T160000Z
DTEND:20230210T170000Z
SUMMARY:CANCELLED Physiology Seminar: Defective hormonal signaling and Alzh
 eimer’s disease
URL:/physiology/channels/event/cancelled-physiology-se
 minar-defective-hormonal-signaling-and-alzheimers-disease-345866
END:VEVENT
END:VCALENDAR