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UID:20250506T191017EDT-9290FJMTwI@132.216.98.100
DTSTAMP:20250506T231017Z
DESCRIPTION:The Meloche laboratory studies the signalling mechanisms that c
 ontrol cell division\, differentiation and survival of normal and cancer c
 ells. The research aims to identify novel targets for the development of i
 nnovative mechanism-based cancer therapies. Current research efforts are f
 ocused on the characterization of the regulatory mechanisms\, signaling ne
 twork and pathophysiological functions of atypical MAP kinases and SRC-fam
 ily kinases\, which are essential regulators of cell proliferation. His la
 boratory has generated several genetically-modified mouse models to study 
 the physiological role of these enzymes and their involvement in cancer an
 d human diseases. They are also using chemical biology and genetic approac
 hes to identify novel oncogenic signalling pathways involved in cancer pro
 gression. This work has led to the identification of the SRC-family kinase
  YES as a new target for liver cancer and other solid cancers. The Meloche
  laboratory is actively involved in drug discovery projects aimed at devel
 oping novel small molecule inhibitors of SRC-family kinases and ERK3/4 MAP
  kinases.\n\nThis seminar will take place in-person and online (details in
  attached poster below)\n
DTSTART:20230428T150000Z
DTEND:20230428T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: YES tyrosine kinase as an oncogenic driver of l
 iver cancer
URL:/physiology/channels/event/physiology-seminar-yes-
 tyrosine-kinase-oncogenic-driver-liver-cancer-347487
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