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UID:20250802T194716EDT-4857kJNuXl@132.216.98.100
DTSTAMP:20250802T234716Z
DESCRIPTION:The human brain consumes 40% of the body’s oxygen and is perfus
 ed by a vascular plumbing system consisting of large and smaller pipes tha
 t both change shape and are subject to collective network reorganization w
 ith disease and aging. The smallest vascular structure\, the capillary\, i
 s a central site of oxygen exchange\, an exchange essential for normal fun
 ctioning of the brain. Recent evidence points to capillaries\, and their p
 roperties as key to understand in this context. Using non-linear microscop
 y and exploiting novel oxygen sensitive nanoprobes\, my group uncovered mi
 crovascular changes with increasing age: increased capillary flow heteroge
 neity/disorganization leading to sparse local micropockets of hypoxic tiss
 ue in the brain where neurons potentially die. Underlining the mechanistic
  importance of these changes is that they were also observed in atheroscle
 rosis and Alzheimer’s disease (AD). These observations will be described a
 nd put into the context of the recently observed capillary stalling phenom
 enon.\n\n \n\nThis seminar will take place in-person and on line \, detail
 s in attached poster below. All are welcome!\n
DTSTART:20231124T160000Z
DTEND:20231124T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Dr. Frédéric Lesage\, 'Capillary stalling and h
 ypoxic micropockets: two sides of the same phenomenon?'
URL:/physiology/channels/event/physiology-seminar-dr-f
 rederic-lesage-capillary-stalling-and-hypoxic-micropockets-two-sides-same-
 352674
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