QLS Seminar Series - Anne-Louise Leutenegger | Quantitative Life Sciences

In-person class cancellation and work-from-home / Annulation des cours en pr茅sentiel et t茅l茅travail

Updated: Tue, 03/10/2026 - 17:14

In-person class cancellation and work-from-home / Annulation des cours en pr茅sentiel et t茅l茅travail. McGILL ALERT! Due to freezing rain all in-person classes and activities on Wednesday, March 11, will be cancelled. Staff are asked not to come to campus tomorrow unless they are required on site by their supervisor to perform necessary functions and activities. See your 涩里番 email for more information.
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ALERTE McGILL! En raison de la pluie vergla莽ante, tous les cours et activit茅s en pr茅sentiel pr茅vus pour le mercredi 11 mars sont annul茅s. Nous demandons au personnel de ne pas se pr茅senter sur le campus demain, 脿 moins que leur superviseur ne leur demande d鈥櫭猼re sur place pour accomplir des fonctions ou activit茅s n茅cessaires au fonctionnement du campus. Pour plus d鈥檌nformations, veuillez consulter vos courriels de 涩里番.

Event

QLS Seminar Series - Anne-Louise Leutenegger

Tuesday, April 13, 2021 12:00to13:00

QC, CA

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Genomic inbreeding and its contribution to the study of human diseases

Anne-Louise Leutenegger, Inserm NeuroDiderot
Tuesday April 13, 12-1pm
Zoom Link:聽

Abstract:聽Couples of close relatives (second cousins or closer) and their offspring represent about 10% of the world population. Related individuals are individuals who have at least one ancestor in common. The genetic consequence of this shared ancestry is that alleles may be received identical by descent (IBD) from one of the ancestors. These IBD alleles may be shared between individuals (relatedness) or within an individual (inbreeding).

Historically the estimation of relatedness and inbreeding has been done relying on pedigree information. But with the advent of high throughput technologies allowing to produce large amounts of genomic information, reliable estimation from the genome can now be obtained.

I will first present how this dense genomic information can be used to estimate inbreeding, how it differs from the information provided by pedigrees and which inference models are used and their relative merits. I will then present how these developments have been of interest for disease gene mapping.