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UID:20251007T113527EDT-9242XrUfDF@132.216.98.100
DTSTAMP:20251007T153527Z
DESCRIPTION:Lipoma Preferred Partner (LPP) Regulates Breast Cancer Cell Mig
 ration and Invasion\n\nClaire Brown\, ɬÀï·¬\n	Tuesday March 24\
 , 12-1pm\n	Montreal Neurological Institute\, deGrandpre Communications Cent
 re\n\nAbstract: In 2019\, over 220\,000 Canadians will be diagnosed with c
 ancer and 82\,000 will die of the disease. Approximately 90% of cancer rel
 ated deaths are the result of metastatic disease. This is indeed the case 
 for breast cancer where metastasis is the deadliest aspect of disease prog
 ression. We have implicated the Lipoma Preferred Partner (LPP) protein as 
 an important mechanosensitive integrator of TGFβ-mediated breast cancer ce
 ll migration and invasion\, two cellular processes that are critical for c
 ancer metastasis. Two important structures that regulate migration and inv
 asion are cellular adhesions (migration) and invadopodia (invasion). Cell-
 matrix adhesions are dynamic structures that link the extracellular matrix
  to the internal cytoskeleton. Adhesions are tightly regulated in space an
 d time to control cell migration. In turn\, invadopodia are structures tha
 t form enabling cells in exit primary tumors\, enter the blood stream and 
 enter distant tissues at sites of metastasis. Our work shows that LPP is a
 n important regulator of cell-matrix adhesion and invadopodia formation an
 d substrate degradation in response to TGFβ stimulation. We demonstrate th
 is in several cell breast cancer cell lines including triple negative 4T1 
 cells. Using biophysical tools and quantitative imaging we link LPP to reg
 ulation of cell migration through regulation of adhesion dynamics\, mechan
 osensing\, regulation of tension at individual adhesions and invasion on s
 ubstrates with variable biomechanical properties.\n
DTSTART:20200324T160000Z
DTEND:20200324T170000Z
LOCATION:deGrandpre Communications Centre\, Montreal Neurological Institute
 \, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:QLS Seminar Series - Claire Brown
URL:/qls/channels/event/qls-seminar-series-claire-brow
 n-320989
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