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DTSTAMP:20250505T215008Z
DESCRIPTION:Lipoma Preferred Partner (LPP) Regulates Breast Cancer Cell Mig
 ration and Invasion\n\nClaire Brown\, ɬÀï·¬\n	Tuesday November 
 17\, 12-1pm\n	Zoom Link: https:/mcgill.zoom.us/j/91589192037\n\nAbstract: I
 n 2019\, over 220\,000 Canadians will be diagnosed with cancer and 82\,000
  will die of the disease. Approximately 90% of cancer related deaths are t
 he result of metastatic disease. This is indeed the case for breast cancer
  where metastasis is the deadliest aspect of disease progression. We have 
 implicated the Lipoma Preferred Partner (LPP) protein as an important mech
 anosensitive integrator of TGFβ-mediated breast cancer cell migration and 
 invasion\, two cellular processes that are critical for cancer metastasis.
  Two important structures that regulate migration and invasion are cellula
 r adhesions (migration) and invadopodia (invasion). Cell-matrix adhesions 
 are dynamic structures that link the extracellular matrix to the internal 
 cytoskeleton. Adhesions are tightly regulated in space and time to control
  cell migration. In turn\, invadopodia are structures that form enabling c
 ells in exit primary tumors\, enter the blood stream and enter distant tis
 sues at sites of metastasis. Our work shows that LPP is an important regul
 ator of cell-matrix adhesion and invadopodia formation and substrate degra
 dation in response to TGFβ stimulation. We demonstrate this in several cel
 l breast cancer cell lines including triple negative 4T1 cells. Using biop
 hysical tools and quantitative imaging we link LPP to regulation of cell m
 igration through regulation of adhesion dynamics\, mechanosensing\, regula
 tion of tension at individual adhesions and invasion on substrates with va
 riable biomechanical properties.\n
DTSTART:20201109T153000Z
DTEND:20201109T153000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Claire Brown
URL:/qls/channels/event/qls-seminar-series-claire-brow
 n-326000
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