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DESCRIPTION:The MeshCODE theory – does our brain store memories in a binary
  format?\n\nBen Goult\, University of Kent\n	Tuesday November 30\, 12-1pm\n
 	Zoom Link: https://mcgill.zoom.us/j/85428056343\n\nAbstract: Cell adhesion
  to the extracellular matrix (ECM)\, mediated by integrins\, is exquisitel
 y sensitive to biochemical\, structural\, and mechanical features of the E
 CM. Talin\, the primary link between integrins and the actin cytoskeleton\
 , coordinates the binding of a wide range of cytoskeletal and signaling ad
 aptors in a force-dependent manner. Our work has defined talin as a major 
 mechanosensitive signalling hub. More recently we have discovered that tal
 in has “molecular memory” and so provides organisms with a way to store da
 ta\, through persistent alterations in protein conformation. In this talk 
 I discuss the implications of these findings and describe a novel role for
  integrin adhesions in data-storage leading to a novel theory of how memor
 ies are stored in our brain. The MeshCODE theory presented here provides a
 n original concept for the molecular basis of memory storage. I propose th
 at memory is biochemical in nature\, written in the form of different prot
 ein conformations in each of the trillions of synapses. Based on establish
 ed biophysical principles\, a mechanical basis for memory would provide a 
 physical location for data storage in the brain. Furthermore\, the convers
 ion and storage of sensory and temporal inputs into a binary format identi
 fies an addressable read/write memory system supporting the view of the mi
 nd as an organic supercomputer.\n\nReferences:\n	Talin in mechanotransducti
 on and mechanomemory at a glance. Goult BT\, Brown NH\, Schwartz MA. J Cel
 l Sci. 2021 Oct 15\;134(20):jcs258749. doi: 10.1242/jcs.258749\n	The Mechan
 ical Basis of Memory - the MeshCODE Theory. Goult BT. Front Mol Neurosci. 
 2021 Feb 25\;14:592951. doi: 10.3389/fnmol.2021.592951\n
DTSTART:20211130T170000Z
DTEND:20211130T180000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Ben Goult
URL:/qls/channels/event/qls-seminar-series-ben-goult-3
 34788
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