Event
MIAM Connect Seminar - Multiscale Rheology and Disease Dynamics
Friday, March 13, 2026 13:00to14:15
Adams Building
Adams Building, Room 3 (Engine), 3450 rue University, Montreal, QC, H3A 0E8, CA
Refreshments provided.
ADAM HENDRICKS /聽How Polyglutamine Expansions Modulate the Mechanics and Dynamics of Huntingtin-RNA Condensates
Huntingtin, a 350-kDa protein with essential functions in development, intracellular transport, and transcription, forms co-condensates with other proteins and RNA. Condensates may function to regulate transcription and control huntingtin鈥檚 association with other proteins. Polyglutamine expansions in huntingtin, the cause of Huntington鈥檚 Disease, alter condensate mechanics and dynamics.
CAROLINE WAGNER /聽Transport in Mucus in the Bulk and at Interfaces
In-host, mucus serves as a physical and biochemical barrier, hindering pathogens from reaching underlying susceptible cells. In this talk, we will discuss transport through mucus for a variety of model nanoparticle systems, and how this is affected by aerosol delivery of these particles to complex fluid interfaces. Throughout, we discuss the important implications of these processes for the spread of infectious disease.