BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20260111T042032EST-35226SZ618@132.216.98.100
DTSTAMP:20260111T092032Z
DESCRIPTION:Title: Doubly-Robust Bayesian Estimation of Individualized Trea
 tment Rules Using Network Meta-Analysis.\n\nAbstract\n\n \n\nAn optimal In
 dividualized Treatment Rule (ITR) is a function that takes a patient's cha
 racteristics\, such as demographics\, biomarkers\, and treatment history\,
  and outputs a treatment that is expected to give the best outcome for tha
 t patient. When estimating ITRs from individual studies\, power to detect 
 important treatment-covariate interactions is often low. Additionally\, al
 l treatments of interest may not be compared head-to-head in a single stud
 y. Network Meta-Analysis (NMA) is a method of synthesizing data from multi
 ple studies to estimate the relative effects of a set of treatments. Two-s
 tage ITR NMA is an emerging technique for the estimation of ITRs that can 
 improve power and simultaneously consider all relevant treatment options w
 hile protecting sensitive data. In the first stage\, study-specific ITRs a
 re estimated\, and in the second stage\, the study-specific ITRs are poole
 d using an NMA model. In this talk\, we propose a doubly-robust and fully 
 Bayesian approach to estimating study-level ITRs. We also show how missing
 -at-random outcomes can be accounted for in this approach. We then propose
  a Bayesian NMA model for pooling the study-level ITRs that leverages the 
 full covariance matrix of the estimates. Finally\, we use the methods to e
 stimate an optimal ITR for major depressive disorder using data from three
  adaptive trials.\n\n \n\nSpeaker bio\n\n \n\nAugustine Wigle currently ho
 lds an NSERC Postdoctoral Fellowship at ɬÀï·¬ supervised by Pr
 of. Erica Moodie in the Department of Epidemiology\, Biostatistics and Occ
 upational Health. She is interested in Bayesian methods\, network meta-ana
 lysis\, and precision medicine. For more information\, please visit:\n\nht
 tps://sites.google.com/view/augustinewigle\n
DTSTART:20260114T203000Z
DTEND:20260114T213000Z
LOCATION:Room 1140\, New ɬÀï·¬ Dental Clinic\, CA\, QC\, Montreal\, H3A 1G
 1\, 2001\, avenue ɬÀï·¬ College
SUMMARY:Augustine Wigle (ɬÀï·¬ )
URL:/science/channels/event/augustine-wigle-mcgill-370
 232
END:VEVENT
END:VCALENDAR