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DTSTAMP:20260115T031013Z
DESCRIPTION:This annual lecture honours Dr. Albert Aguayo\, OC\, FRCP\, Pro
 fessor Emeritus founder and former Director of the Centre for the Research
  in Neuroscience at ɬ�﷬.\n\n\nRegister Now\n\nTo watch onlin
 e\, click here\n\n\nDo You Remember? Let Me Explain You How.\n\nTalk Abstr
 act: A general wisdom is that only selected aspects of our experiences are
  remembered. Extensive work over the past decades has shown that sleep pla
 ys a critical role in the consolidation process of memory. We identified a
  brain pattern\, known as sharp wave-ripple (SPW-R)\, that supports the “r
 eplay” of waking experience in compressed snippets (~100 ms) in the hippoc
 ampal-neocortical circuits. SPW-Rs evolved in evolution to support body fu
 nctions\, such as regulating glucose levels and hormone release\, and we e
 xapted to serve cognitive functions\, parallel with the development of the
  neocortex. SPW-Rs are present in the resting and waking brain\, and these
  compressed information packages repeat fragments of learned information 2
 000 to 4000 times each night during non-REM sleep. However\, brain mechani
 sms that select experiences for lasting memory are not known. To address t
 he selection (or “credit assignment”) problem\, we combined large-scale ne
 ural recordings with a novel application of dimensionality-reduction techn
 iques in rodents. When the brain state changed from theta oscillations dur
 ing maze exploration to SPW-Rs during reward consumption\, the spike conte
 nt of SPW-Rs decoded the trial in which they occurred. In turn\, during po
 st-experience sleep\, SPW-Rs continued to replay those trial contents that
  were reactivated most frequently during waking SPW-Rs. These findings dem
 onstrate that the replay content of awake SPW-Rs provides a tagging mechan
 ism to select critical aspects of experience that are consolidated and pre
 served for future use during sleep. In related experiments\, we aborted or
  prolonged SPW-Rs by closed-loop optogenetic methods and demonstrated impa
 ired and enhanced memory of the previous experience\, respectively. Thus\,
  SPW-Rs provide a hippocampal mechanism for prioritizing and tagging aspec
 ts of experience and consolidating them during post-learning sleep.\n\nGyö
 rgy Buzsáki\n\n\n\nGyörgy Buzsáki is Biggs Professor of Neuroscience at Ne
 w York University. His main focus is “neural syntax”\, i.e.\, how the nume
 rous brain rhythms organize segmentation of neural information to support 
 cognitive functions. He is among the top 0.1% of most-cited neuroscientist
 s and an elected member of the National Academy of Sciences USA\, Academia
 e Europaeae\, and the Hungarian Academy of Sciences. He sits on the editor
 ial boards of several leading neuroscience journals\, including Science an
 d Neuron\, honoris causa at Université Aix-Marseille\, France and Universi
 ty of Kaposvar\, Hungary and University of Pécs\, Hungary. He is a co-reci
 pient of the 2011 Brain Prize and the recipient of the 2020 Ralph Gerard A
 ward (SFN). (Books: G. Buzsáki\, Rhythms of the Brain\, Oxford University 
 Press\, 2006\; The Brain from Inside Out\, OUP\, 2019)\n\n\nThis event is 
 generously supported by the Rose Wiselberg Foundation.\n\n \n
DTSTART:20260427T200000Z
DTEND:20260427T210000Z
LOCATION:de Grandpre Communications Centre\, The Neuro
SUMMARY:Albert Aguayo Lecture: Do You Remember? Let Me Explain You How.
URL:/spot/channels/event/albert-aguayo-lecture-do-you-
 remember-let-me-explain-you-how-367445
END:VEVENT
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