BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260115T224903EST-4351HdzUoO@132.216.98.100 DTSTAMP:20260116T034903Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegister Now\n\nTo watch online\, click here\n\n\nC all for Abstracts\n\nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at The Neuro Epilep sy Day 2026. \n\nWe encourage abstracts at any stage of a project’s develo pment—from literature reviews and research questions to pilot data and ong oing studies.\n\nSubmission deadline: March 23\, 2026\n\nSubmit Your Abstr act Here\n\nSelected abstracts will be featured in the poster session\, an d five outstanding posters will be invited to give a short oral presentati on during the program.\n\n\n\n \n Programme\n Speakers\n The Pierre Gloor Lect ure\n Location\n Sponsors\n Scientific Committee\n \n\n \n Thursday\, May 28\, 2 026\n\n Preliminary Program \n\n \n \n \n 9:15\n \n Arrival & Registration\n \n \n \n 9:30\n \n Lab Tours\n\n Neuroimaging\, EEG/FMRI\, MEG\,\n \n \n \n 10:45\n \n Wel come and Introduction\n\n Boris Bernhardt\, PhD\n Associate Professor of Neu rology and Neurosurgery\n Epilepsy Group Leader (Research)\, The Neuro\n \n \n \n 11:00\n \n Keynote Lectures\n\n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n Irene Wang\, PhD\n Research Director and Staff Scient ist\n Cleveland Clinic Epilepsy Center\n\n Networks\n\n Seok-Jun Hong\, PhD\n Associate Professor of Biomedical Engineering Department\, SKKU\n Sungkyunk wan University - ɬÀï·¬\n\n Surgical Perspectives\n\n Roy William Dudley\, FRCSC\n Assistant Professor\, Department of Pediatric Surgery\, D epartment of Neurology & Neurosurgery\n Montreal Children's Hospital\n\n Ale xander G. Weil\, FRCSC\, FACS\n Associate Professor\, Neurosurgeon\, Resear cher\, Director\n University of Montreal - Sainte-Justine Hospital Research Centre\n\n Jeffery Allan Hall\, FRCSC\n Assistant Professor of Neurology an d Neurosurgery\n Epilepsy Programme\, Neurosurgery Clinic\, Brain Tumour Cl inic\n \n \n \n 1:00\n \n Lunch and Poster Session\n \n \n \n 2:00\n \n Oral Presentat ions\n \n \n \n 3:00\n \n Coffee Break\n \n \n \n 3:15\n \n Pierre Gloor Lecture\n\n Br ain Mosaicism in Epilepsies and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research director and Group Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4:15\n \n Discussion Panel\n\n Samantha Audrain\, PhD \n\n Alexa nder Barnett\, PhD \n\n Stéphanie Baulac\, PhD \n\n Andrea Bernasconi\, MD   \n\n Boris Bernhardt\, PhD \n\n Neda Ladbon-Bernasconi\, PhD  \n\n Sara Lariv iere\, PhD  \n\n Raluca Pana\, MD\, FRCP\, CSCN \n\n Myriam Srour\, MDCM\, P hD \n \n \n \n 5:00\n \n Cocktail Reception (onsite)\n \n \n \n \n \n\n \n Speakers\n\n Keynotes:\n\n Irene Wang\n\n Dr. Irene Wang is the Research Director and Ful l Staff at the Cleveland Clinic Epilepsy Center and an Associate Professor of Neurology at the Cleveland Clinic Lerner College of Medicine. Her rese arch advances surgical treatments for MRI-negative epilepsy patients throu gh innovative imaging and neurophysiology techniques. As a trained biomedi cal engineer with a strong foundation in clinical neurophysiology and neur oimaging\, Dr. Wang has pioneered the integration of advanced imaging into clinical practice to enhance patient care. She has authored over 120 peer -reviewed papers and serves as Associate Editor for Epilepsia. Dr. Wang ha s received continuous support from the National Institute of Health and se rves as a charter member of the NIH Imaging Technology for Neuroscience st udy section. Dr. Wang also chairs the MRI Data Task Force of the ILAE Big Data Commission and serves on the Imaging Task Force of the ILAE Diagnosti c Methods Commission.\n \n Improving Epilepsy Surgery Planning Using MR Fing erprinting\n More details to come...\n\n  \n\n Stéphanie Baulac | Pierre Gloo r Lecture\n\n Stéphanie Baulac is a Research Director at Inserm and Group L eader at the Paris Brain Institute (ICM) of the MOSAIC Team « Genetic Mosa icism in Epilepsy and Neurodevelopmental Disorders » Her team implements a comprehensive translational approach spanning from the identification and characterization of somatic mutations in brain tissues obtained from pati ents undergoing epilepsy surgery to in-depth functional analysis\, combini ng functional testing on patient-derived brain organoids\, and mouse model s. \n \n Brain Mosaicism in Epilepsies and Cortical Malformations\n Focal cor tical dysplasia type II (FCDII) is a cortical malformation causing refract ory epilepsy\, resulting from developmental somatic mutations in mTOR path way genes. To understand how these mutations create a mosaic pattern of af fected cells and lead to cortical dyslamination\, we performed comprehensi ve single-nucleus analyses of surgical samples from genetically-characteri zed FCDII patients. By combining genotyping and transcriptomics at single- cell resolution\, we revealed that mutations predominantly affect glutamat ergic neurons and astrocytes\, creating distinct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-spe cific dysregulation of synaptic and neurodevelopmental pathways that likel y contribute to epileptogenesis. Notably\, our analysis of cytomegalic cel ls uncovered pronounced alterations in mitochondrial metabolism pathways a nd cellular senescence. We uncover a signature associated with cellular se nescence in abnormal FCDII cells and further provide evidence in preclinic al FCDII mouse models that senolytic agents could offer a novel therapeuti c strategy for this disorder.\n\n  \n\n \n \n\n \n The Pierre Gloor Lecture\n\n The Pierre Gloor Lecture celebrates the life and legacy of Pierre Gloor (1 923–2003)\, who joined The Neuro (Montreal Neurological Institute-Hospital ) in 1952 as a fellow in electroencephalography and neurophysiology. He tr ained under Wilder Penfield and Herbert Jasper and earned his PhD from McG ill University in 1957. Gloor collaborated closely with clinical and resea rch teams at The Neuro in advancing the understanding and treatment of epi lepsy\, gaining international recognition for his contributions to the fie ld.\n\n Brain Mosaicism in Epilepsies and Cortical Malformations\n\n Speaker : Stéphanie Baulac\, PhD\n Research director and Group Leader\n Inserm and P aris Brain Institute (ICM)\n\n Focal cortical dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy\, resulting from devel opmental somatic mutations in mTOR pathway genes. To understand how these mutations create a mosaic pattern of affected cells and lead to cortical d yslamination\, we performed comprehensive single-nucleus analyses of surgi cal samples from genetically-characterized FCDII patients. By combining ge notyping and transcriptomics at single-cell resolution\, we revealed that mutations predominantly affect glutamatergic neurons and astrocytes\, crea ting distinct transcriptional programs in both mutated and non-mutated cel ls. This mosaicism drives cell-type-specific dysregulation of synaptic and neurodevelopmental pathways that likely contribute to epileptogenesis. No tably\, our analysis of cytomegalic cells uncovered pronounced alterations in mitochondrial metabolism pathways and cellular senescence. We uncover a signature associated with cellular senescence in abnormal FCDII cells an d further provide evidence in preclinical FCDII mouse models that senolyti c agents could offer a novel therapeutic strategy for this disorder.\n\n   \n\n \n \n\n \n Location\n\n The Montreal Neurological Institute and Hospital i s at 3801 University Street\, north of Pine Avenue West\, on the ɬÀï·¬ Un iversity campus opposite the former Royal Victoria Hospital.\n\n Montreal i s served by highway Routes 10\, 15\, 20 and 40\, and by Greyhound Bus\, Vi a Rail and the P-E-Trudeau airport. In the city\, bus and metro service is provided by the Société de transport de Montréal (STM).\n\n Wheelchair acc ess\n\n A wheelchair accessible entrance is on University Street north of t he main entrance. Another wheelchair accessible entrance is in the loading area behind the building: to enter the loading area\, turn into the drive way south of the main entrance. Please note\, there is no parking in the l oading area.\n\n Parking\n\n Parking near the MNI is sometimes difficult. Th ere are parking meters on University Street and a parking lot north of the main entrance. To enter the lot\, turn right into the driveway toward Mol son Stadium.\n\n Information about parking fees\n\n Taxi Stand\n\n There is a taxi stand on University Street across from the main entrance. You may ca ll a cab from the free taxi phone in the main lobby near the Security Desk .\n\n Access by Public Transportation (STM website)\n\n Bus\n\n There are fou r bus stops within walking distance:\n\n \n Bus 144 stops at Pine Avenue and University Street\n Bus 356 stops at Sherbrooke Street and University Stre et (Nightbus)\n Bus 107 stops at Pine Avenue and Docteur Penfield\n Bus 24 s tops at Sherbrooke Street and University Street\n \n\n Metro\n\n Take the Met ro Green Line to the ɬÀï·¬ station. Walk north on University Street and c ross Pine Avenue. The main entrance is on the right\, past the flags.\n\n J eanne Timmins Amphitheatre\n\n \n Enter the main lobby\, turn left\, and go down the hallway to the end.\n Turn right and go down the second hallway un til you see another hallway on the left.\n This hallway leads to the Jeanne Timmins Foyer.\n On your right are the Jeanne Timmins Amphitheatre entranc e doors.\n \n \n\n \n Sponsors \n \n\n \n Scientific Committee\n\n Sam Audrain\n\n Alexander Barnett\n\n Boris Bernhardt\n\n Sara Larivière\n\n Raluca Pana\n\n D ebbie Rashcovsky\n\n Myriam Srour\n\n  \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/spot/channels/event/neuro-epilepsy-day-2026-epile psy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR