Welcome to our Lab
We focus on improving outcomes in the treatment of gastric and esophageal cancers, as well as on the basic mechanisms involved in resistance to neoadjuvant/adjuvant therapy and the development of model systems/tumour avatars to investigate and identify clinically useful approaches to abrogate such resistance. We are involved with several large team projects, including studies funded by the Cancer Research UK Grand Challenge and Marathon of Hope mechanisms.
Principal Investigator听
Research Interests
- Basic Research:
- Influence of Systemic Inflammation in Cancer Metastasis
- Toll like receptor host/cancer cell signaling in cancer metastasis
- Neutrophil facilitated cancer progression
- Molecular Determinants of Gastric/Esophageal Cancer
- Discovery of putative driver variants
- Molecular determinants of peritoneal metastasis
- Mechanisms of Therapy Resistance in Esophageal Adenocarcinoma
- Chronic Inflammation Associated Cancers 鈥� Pathogenesis of GERD mediated Barrett鈥檚 adenocarcinoma
- Modelling Cancer 鈥� organoids and organ chip
- Influence of Systemic Inflammation in Cancer Metastasis
- Clinical Research:
- Clinical Chemotherapy Trials for Thoracic Malignancies
- Neoadjuvant chemotherapy鈥揼astric and esophageal cancer
- Adjuvant chemotherapy鈥搇ung cancer
- Effect of Pre-operative Rehabilitation on Complications Following Lung Surgery
- Laparoscopic Surgery for Benign Esophageal Disease-Outcome Measures
- Treatment of Esophageal Cancer鈥揙utcome Measures
- Enhanced Recovery Programsin Thoracic Oncology Surgery
- Clinical Chemotherapy Trials for Thoracic Malignancies
Research Expertise
Cancer Diagnosis and Detection, Cancer of the Digestive System, Cell Therapy of Cancer, Host-Tumour Interaction, Lung Cancer
Most Significant Contributions
Lorenzo Ferri is the holder of the David S. Mulder Endowed Chair in Surgery and a tenured Professor in the Departments of Surgery and Oncology at 涩里番 in Montreal Canada. He is director of the Division of Thoracic and Upper Gastrointestinal Surgery and heads the Upper Gastrointestinal Cancer Program at 涩里番. Dr Ferri couples this clinical activity with an active translational and fundamental research program investigating the mechanisms of therapy resistance in gastro-esophageal adenocarcinoma and the inflammatory basis of cancer progression for which he is the recipient of numerous peer review grants from the Canadian Institutes of Health Research, Canadian Cancer Society, United States Department of Defense, and a Grand Challenge from Cancer Research UK, totaling over 25 million dollars. Dr Ferri has published over 250 peer reviewed articles and is the current president of the International Society for Diseases of the Esophagus and immediate past president of the International Society for Digestive Surgery.
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