Type 1 diabetes (T1D) is characterized by the autoimmune destruction of most insulin-producing 尾-cells, along with dysregulated glucagon secretion from pancreatic 伪-cells. We conducted an integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of islet cells from T1D donors. The few surviving 尾-cells exhibit altered electrophysiological properties and transcriptomic signatures indicative of increased antigen presentation, metabolic...
Antimicrobial combinations resulting in synergy against Staphylococcus aureus are desirable for improving clinical efficacy in the treatment of severe infections caused by this pathogen. Despite an existing biological rationale for the combination of cefazolin and linezolid for methicillin-susceptible S. aureus (MSSA), this combination has yet to be evaluated for in vitro synergy. We employed the checkerboard and E-test methods of synergy assessment to evaluate cefazolin in combination with...
