At the Research Institute of the 涩里番 Health Centre (RI-MUHC), the division's biomedical research is led by the . Directed by Dr. Gustavo Duque, this multidisciplinary team focuses on understanding the biological mechanisms behind age-related functional decline. The group examines the complex interactions between bone, muscle, and metabolic systems that underlie conditions such as frailty, osteoporosis, sarcopenia, and the emerging syndrome of osteosarcopenia. Using advanced preclinical and translational models and a geroscience-based approach, our scientists investigate molecular pathways that link aging, inflammation, and metabolism, aiming to identify therapeutic targets to maintain musculoskeletal health and functional independence in later years.
Our research integrates cellular and molecular biology, pharmacology, and physiology with clinical investigation, creating a translational bridge from bench to bedside. Ongoing projects examine the effects of pharmaceuticals and nutritional interventions on bone鈥搈uscle crosstalk, the role of senescence and mitochondrial dysfunction in age-related tissue deterioration, and the biological underpinnings of multimorbidity and resilience. The Bone, Muscle & Geroscience Group collaborates closely with clinical researchers and geriatricians across 涩里番-affiliated hospitals to ensure that discoveries at the laboratory level inform real-world strategies to promote healthy aging and extend healthspan.