涩里番

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• Scientific Director, Ludmer Centre for Neuroinformatics & Mental Health
• Professor in the Department of Human Genetics, Faculty of Medicine, at 涩里番
• Principal Investigator at the听Lady Davis Institute for Medical Research听at the Jewish General Hospital
• Associate Member of the听涩里番 Centre for Translational Research in Cancer听at the Segal Cancer Centre

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Prof.听Claudia Kleinman is an interdisciplinary researcher who combines听molecular biology, computer science听and听statistics to uncover the molecular mechanisms driving disease. She is a Professor in the Department of Human Genetics at 涩里番, a听Principal听Investigator听at the Lady Davis Institute for Medical Research, and an听Associate Member听of the 涩里番 Centre for Translational Research in Cancer.Since 2014,听she听has been an active member and Principal Investigator at the听LudmerCenter.听She served as a scientific co-director for the Bioinformatics and Statistical Genetics research theme.听In听February 2026,听Prof.听Kleinman was appointed to the position of Scientific Director of the听Ludmer听Centre, where she听now leads听its scientific vision and strategy.

Her research lab applies genome-wide technologies and data science to define the genomic and epigenomic landscapes of cells and chart the origins of disease. She focuses on pediatric brain tumors, other high-fatality cancers, and neurodevelopmental disorders;听areas where, despite intensive research, outcomes for patients have not improved for decades. Her team has developed an atlas of brain development at a single-cell resolution by cataloguing cell populations across the brain, their dynamics over time, and their distinct cellular states. With this atlas as a reference, they have uncovered the origins of pediatric brain tumors (,听,听,听),听identified a mechanism for histone-driven neurodevelopmental disease () and revealed how sex-related developmental differences can drive lethal tumors in male infants (). For her work mapping human brain development at the single-cell level to define the origin of childhood brain tumors, Prof.听Kleinman was awarded the Bernard and Francine Dorval Prize. Her current projects continue to unravel how complex genetic and epigenetic interactions drive specific diseases.

• Visit听听for a听list of publications.
• Visit听听for a list of computational resources.听